Evidence map›Paper›PMID 42687492›Full record

ArticleRNA biology2026

Single-molecule insights into SAM-I riboswitch ligand binding using scaled magnetic force spectroscopy with comparison to conventional biophysical methods.

Zhen Wang, Henning Labuhn, Rémi Moulinas, David Salthouse, Akifumi Nakamura, Yoshihiro Akahori, Airi Kon, Shohei Kawasaki, Adeline Feri, Pascale Beurdeley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhen WangDepixus SAS, Courbevoie, France.
Henning LabuhnDepixus SAS, Courbevoie, France.
Rémi MoulinasDepixus SAS, Courbevoie, France.
David SalthouseDepixus SAS, Courbevoie, France.
Akifumi NakamuraDaiichi Sankyo Co., Ltd., Shinagawa-ku, Japan.
Yoshihiro AkahoriDaiichi Sankyo Co., Ltd., Shinagawa-ku, Japan.
Airi KonDaiichi Sankyo Co., Ltd., Shinagawa-ku, Japan.
Shohei KawasakiDaiichi Sankyo Co., Ltd., Shinagawa-ku, Japan.
Adeline FeriDepixus SAS, Courbevoie, France.
Pascale BeurdeleyDepixus SAS, Courbevoie, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biophysical methods are widely used for drug discovery, with surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) being amongst the most used techniques. However, these types of bulk or ensemble methods do not provide single-molecule resolution or structural and mechanistic insights, so that researchers are forced to rely upon a battery of complementary techniques. Here, we used a scaled magnetic force spectroscopy (MFS) instrument system capable of analysing hundreds of single molecules in parallel and obtaining dynamic conformational insights. Taking the

Indexed as

RiboswitchS-AdenosylmethionineSingle Molecule ImagingCalorimetryLigandsMolecular Dynamics SimulationNucleic Acid ConformationS-AdenosylhomocysteineSurface Plasmon ResonanceLigandsRiboswitchS-AdenosylhomocysteineS-Adenosylmethionineisothermal titration calorimetrymagnetic force spectroscopyRNASAM-I riboswitchsingle-molecule techniquesurface plasmon resonance

Identifiers

PMID42687492
PMCPMC13556962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.