ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026
BRD4 inhibition mitigates acute and chronic corneal injury following topical nitrogen mustard exposure.
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Corneal chemical injury, including mustard vesicant injury, remains a clinical challenge with limited therapeutic options. To enable effective mechanistic and therapeutic studies, we developed a mouse model of nitrogen mustard (NM)-induced corneal injury using a 3D-molded, cap-shaped filter paper conforming to the corneal surface to generate reproducible injuries. Multimodal in vivo imaging and histological assessment revealed an injury course characterized by acute epithelial disruption, stromal edema, and inflammation, followed by transient partial recovery and chronic stromal remodeling with persistent endothelial loss. After NM exposure, bromodomain (BD)-containing protein 4 (BRD4) expression and activity were upregulated. Short-term topical BRD4 inhibition with JQ1 reduced acute corneal inflammation (e.g., reducing CD45
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