ReviewTropical medicine and health2026
Ocular manifestations of expanded dengue syndrome: a systematic review with meta-analysis.
Review in Tropical medicine and health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
backgroundOcular manifestations are under-recognized complications of expanded dengue syndrome, with no robust frequency estimates available.
methodsA systematic review was conducted following PRISMA guidelines. Primary studies reporting the frequency of ocular manifestations consistent with expanded dengue syndrome (uveitis, maculopathy, retinal hemorrhage, retinal vasculitis, and optic neuropathy) in patients with confirmed dengue diagnosis were included. Six databases were searched (PubMed, Scopus, Embase, WoS, BIREME-BVS, and SciELO), supplemented by manual searching of reference lists and gray literature, with no date, language, or geographic restrictions. Risk of bias was assessed using the JBI critical appraisal checklist for prevalence studies. Pooled frequency estimates were calculated using a random-effects model with Freeman-Tukey double arcsine transformation. Heterogeneity was evaluated using Cochran's Q, I
resultsEight studies (n = 1,394 patients) were included. Pooled frequency estimates were maculopathy 6% (95% CI 3-10%; I
conclusionsMaculopathy, retinal hemorrhage, and optic neuropathy are relevant complications of expanded dengue syndrome. Clinicians should maintain a high index of suspicion for these ocular manifestations, particularly during the recovery phase.
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