Evidence map›Paper›PMID 42687141›Full record

ArticleThe Journal of physiology2026

N-Arachidonoyl-phosphatidylethanolamide phospholipase D activation by muscarinic receptors.

Natalia Murataeva, Connor Schmitt, Elyssa Hyman, Jim Wager-Miller, Irene Matthews, Ruyi Cai, Shangxuan Cai, Yulong Li, Ken Mackie, Alex Straiker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natalia MurataevaDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Connor SchmittDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Elyssa HymanDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Jim Wager-MillerDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Irene MatthewsDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Ruyi CaiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Shangxuan CaiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Ken MackieDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Alex StraikerDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.ORCID https://orcid.org/0000-0003-0567-5317

Funding

Modulation of pain mechanisms by cannabis-derived phytochemicals.R01AT011162 · NCCIH · QUEEN'S MEDICAL CENTER · PI MACKIE, KENNETH, PENNER, REINHOLD · 2021 to 2025
$3.2M
NCCIH NIH HHS R01 AT011162NIH HHS AT011162
6 · The paper itself

Abstract

The endogenous cannabinoid signalling system consists of G protein-coupled receptors, messengers - 2-arachidonoylglycerol (2-AG) and anandamide - and enzymatic machinery to synthesize and metabolize these messengers. Anandamide is physiologically important, but its synthesis is incompletely understood. N-Arachidonoyl-phosphatidylethanolamide phospholipase D (NAPE-PLD) synthesizes acylethanolamines, including anandamide, but how is NAPE-PLD activated? We used genetically encoded G protein-coupled receptor based (GRAB) sensors for endocannabinoids (eCBs) and immunohistochemistry to investigate. Human embryonic kidney 293 (HEK293) cells natively express G

Indexed as

Phospholipase DReceptor, Muscarinic M3AnimalsArachidonic AcidsEndocannabinoidsGlyceridesHEK293 CellsHumansMiceOxotremorineSubmandibular GlandArachidonic AcidsEndocannabinoidsGlyceridesglyceryl 2-arachidonateNAPEPLD protein, humanOxotremorineoxotremorine MPhospholipase DReceptor, Muscarinic M3acylethanolamineanandamideendocannabinoidN‐arachidonoyl‐phosphatidylethanolamide phospholipase D (NAPE‐PLD)

Identifiers

PMID42687141
PMCPMC13577693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.