Evidence map›Paper›PMID 42687105›Full record

ArticleInternational journal of hematology2026

Pediatric T-cell lymphoblastic lymphoma with t(9;17)(q34;q23)-associated N-terminally truncated NOTCH1 activation: a case report.

Ayako Yamamori, Daichi Sajiki, Yusuke Tsumura, Asahito Hama, Manabu Wakamatsu, Nao Yoshida, Daiki Yamashita, Kotaro Narita, Shinsuke Kataoka, Yusuke Okuno and 2 more

Abstract read
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Article in International journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Road to treatment-free remission in chronic myeloid leukemia.International journal of hematology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ayako YamamoriDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Daichi SajikiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Yusuke TsumuraDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Asahito HamaDepartment of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Aichi Medical Center Nagoya First Hospital, Nagoya, Aichi, Japan.
Manabu WakamatsuDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Nao YoshidaDepartment of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Aichi Medical Center Nagoya First Hospital, Nagoya, Aichi, Japan.
Daiki YamashitaDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Kotaro NaritaDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Shinsuke KataokaDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Yusuke OkunoDepartment of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
Hideki MuramatsuDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. hideki-muramatsu@med.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-8801-0021
Yoshiyuki TakahashiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. ytakaha@med.nagoya-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T-cell lymphoblastic lymphoma (T-LBL) is an aggressive malignancy that comprises 20% of pediatric non-Hodgkin lymphoma cases. Most T-LBLs harbor NOTCH1 point mutations or small indels, which are generally associated with favorable outcomes. In contrast, the clinical impact of structural rearrangements involving NOTCH1 remains poorly understood. We describe the case of a 6-year-old boy with T-LBL carrying a MIR142HG::NOTCH1 fusion from a t(9;17)(q34;q23) translocation, resulting in a truncated, constitutively active NOTCH1 protein. The patient experienced an aggressive course and died shortly after cord blood transplantation. Literature review suggests that 9q34 translocations in T-LBL portend poor prognosis, highlighting truncated NOTCH1 as a potential therapeutic target.

Indexed as

9q34MIR142HG::NOTCH1T-cell lymphoblastic lymphomaTruncated NOTCH1

Identifiers

PMID42687105

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.