Evidence map›Paper›PMID 42686920›Full record

Articlenpj biomedical innovations2026

In vivo adaptive optics retinal imaging reveals rod-mediated cone photoreceptor disorganization in RHO-associated retinitis pigmentosa.

Annette Kaminaka, Tao Liu, John P Giannini, Natalie Toth, Diego Dominguez, Nancy Aguilera, Furu Zhang, Joanne Li, Bin Guan, Brett G Jeffrey and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Annette Kaminaka *National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Tao Liu *National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
John P GianniniNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Natalie TothNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Diego DominguezNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Nancy AguileraNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Furu ZhangNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Joanne LiNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Bin GuanNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Brett G JeffreyNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Alfredo DubraDepartment of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Wadih M ZeinNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Laryssa A HurynNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Johnny TamNational Eye Institute, National Institutes of Health, Bethesda, MD, USA. johnny@nih.gov.ORCID http://orcid.org/0000-0003-2300-0567

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Cellular-level Vascular Oculomics (CVO) for monitoring systemic vascular healthOT2OD038128 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephen A Burns, Amani A Fawzi · 2024 to 2026
$4.8M
Increasing the isoplanatic patch in adaptive optics ophthalmoscopyR01EY032147 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2021 to 2025
$2.4M
Improving rigor and reproducibility in adaptive optics ophthalmoscopyR01EY031360 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2020 to 2023
$2.3M
NEI NIH HHS P30 EY026877NEI NIH HHS P30EY026877, R01EY031360, R01EY032147, OT2OD038128NEI NIH HHS R01 EY031360NEI NIH HHS R01 EY032147NIH HHS Intramural Research ProgramNIH HHS OT2 OD038128
6 · The paper itself

Abstract

Pathogenic variants in the rhodopsin (RHO) gene are the most common cause of autosomal dominant retinitis pigmentosa leading to photoreceptor degeneration. Quantitative imaging using adaptive optics (AO) revealed irregularities in cone organization, even in relatively well-preserved retinal locations. At the leading disease front, rod density was disrupted to a greater extent than cones. Repeated longitudinal measurements demonstrate the possibility of using cone-based metrics for treatment trials to preserve photoreceptor structure.

Identifiers

PMID42686920
PMCPMC13538484

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.