Evidence map›Paper›PMID 42686885›Full record

ArticleNature neuroscience2026

Glutamate concentration tunes AMPA receptor function through conductance-state occupancy.

Gokulakrishna Banumurthy, Reagan L Pennock, Luke T Coddington, Xiaohui Yan, Gabrielle N Smith, Linda Overstreet-Wadiche, Jacques I Wadiche

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gokulakrishna Banumurthy *Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Reagan L Pennock *Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-3976-4641
Luke T Coddington *Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-0785-4231
Xiaohui YanDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-5220-7148
Gabrielle N SmithDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0009-0002-9002-1800
Linda Overstreet-WadicheDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA. lwadiche@uab.edu.ORCID http://orcid.org/0000-0001-7367-5998
Jacques I WadicheDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA. jwadiche@uab.edu.ORCID http://orcid.org/0000-0001-8180-2061

Funding

Newborn Neurons in the Adult Hippocampal NetworkR01NS064025 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2009 to 2023
$5.6M
AMPAR Function in Synaptic and Extrasynaptic MembranesR01NS113948 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WADICHE, JACQUES · 2019 to 2023
$2.1M
Inhibitory Neural Circuits in Dentate FunctionR01NS105438 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2018 to 2022
$2.1M
NINDS NIH HHS R01 NS064025NINDS NIH HHS R01 NS113948U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS105438U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS11394
6 · The paper itself

Abstract

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate excitatory synaptic transmission across the brain and exhibit distinct modes of opening depending on how much glutamate is bound. Despite extensive work on AMPAR conductance states and subunit composition, whether changes in glutamate levels at and around synapses regulate AMPAR function is unknown. Here we show that glutamate concentration ([glutamate]) at mouse interneuron synapses governs key biophysical features of AMPARs that are commonly used to infer subunit composition. Lower [glutamate] reduces hallmark AMPAR properties, including current-voltage rectification, polyamine block and Ca

Identifiers

PMID42686885

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.