Evidence map›Paper›PMID 42686877›Full record

ArticleLung2026

Cough Hypersensitivity in Gastroesophageal Reflux-Induced Chronic Cough: Insights from Reflux Monitoring and High-Resolution Manometry.

Yaxing Zhou, Siwan Wen, Yunfeng Zhang, Tongyangzi Zhang, Shengyuan Wang, Jiaying Yuan, Bingxian Sha, Haodong Bai, Yanan Wu, Li Yu and 1 more

Abstract read
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In one paragraph

Article in Lung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yaxing Zhou *Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Siwan Wen *Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Yunfeng Zhang *Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Tongyangzi ZhangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Shengyuan WangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Jiaying YuanDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Bingxian ShaDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Haodong BaiDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Yanan WuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Li YuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China. 96778@tongji.edu.cn.
Xianghuai XuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China. 05849@tongji.edu.cn.ORCID https://orcid.org/0000-0002-8713-5332

Funding

National Natural Science Foundation of China 82270114National Natural Science Foundation of China 82570146the Clinical Research Program of the Shanghai Municipal Health Commission 20234Y0190the Clinical Research Program of the Shanghai Municipal Health Commission 20254Y0012the Science and Technology Innovation Project of the Shanghai Putuo District Health Commission PTKWWS202604the Seed Program for Research and Transformation of Medical New Technologies of the Shanghai Municipal Health Commission 2025ZZ1028the Shanghai Leading Talent Program of the Eastern Talent Plan BJWS2025069the Shanghai Putuo District Health Commission Clinical Specialty Program of Chronic Obstructive Pulmonary Disease 2024TSZB07
6 · The paper itself

Abstract

backgroundCough hypersensitivity contributes to the heterogeneity of gastroesophageal reflux-induced chronic cough (GERC), but its associated factors remain unclear. This study aimed to investigate factors associated with cough hypersensitivity and evaluate the relative contributions of reflux characteristics and esophageal motility across reflux phenotypes.

methodsThis retrospective study included 195 patients with GERC who underwent 24-hour multichannel intraluminal impedance-pH monitoring and high-resolution esophageal manometry. Cough hypersensitivity was assessed using the Hull Airway Reflux Questionnaire (HARQ). Multivariable regression assessed independent associations with continuous HARQ scores, whereas random forest and SHAP analyses ranked the relative contributions of reflux-related and esophageal motility variables to HARQ score prediction.

resultsPatients with higher cough hypersensitivity exhibited increased capsaicin cough sensitivity, poorer quality of life, lower response rates to standard anti-reflux therapy (all P < 0.05), and a higher prevalence of ineffective esophageal motility (62.1% vs. 32.6%, P < 0.001). In correlation analyses, both reflux burden and esophageal motility were associated with cough hypersensitivity; however, after stratification by reflux phenotype, only esophageal motility remained associated. Multivariable regression showed an independent inverse association between DCI and HARQ scores, while machine-learning analyses ranked DCI as the leading contributor, with both analyses suggesting a more prominent relationship in non-acid GERC.

conclusionsGERC patients with heightened cough hypersensitivity had greater cough-related burden and poorer response to standard anti-reflux therapy. Esophageal motility abnormalities appear to be more closely associated with cough hypersensitivity than reflux burden, particularly in non-acid reflux phenotypes, highlighting a potential role for motility-targeted therapeutic strategies.

Indexed as

Chronic CoughCoughGastroesophageal RefluxAgedChronic DiseaseEsophageal Motility DisordersEsophageal pH MonitoringFemaleHumansMaleManometryMiddle AgedPhenotypeQuality of LifeRetrospective StudiesCough hypersensitivityDistal contractile integralEsophageal motilityGastroesophageal reflux-induced chronic coughNon-acid reflux

Identifiers

PMID42686877

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.