Evidence map›Paper›PMID 42686826›Full record

ArticleScientific reports2026

Sex-specific physical activity thresholds influencing muscle function in older adults with XX genotype of ACTN3 R577X.

Hsiu-Ching Hsu, Wen-Hui Fang, Meng-Chang Lee, Wei-Teing Chen, Yu-Hsuan Chen, Hsiao-Ting Lin, Chih-Chien Wang, Syu-Bi Lin, Cheng-Jung Chen, Mei-Jung Chen and 1 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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11 authors.

Hsiu-Ching HsuGraduate Institute of Medical Sciences, College of Medicine, National Defence Medical University, Taipei City, Taiwan.
Wen-Hui FangDepartment of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei City, Taiwan.
Meng-Chang LeeGraduate Institute of Public Health, College of Public Health, National Defence Medical University, Taipei City, Taiwan.
Wei-Teing ChenDivision of Thoracic Medicine, Department of Medicine, Cheng Hsin General Hospital, Taipei City, Taiwan.
Yu-Hsuan ChenGraduate Institute of Public Health, College of Public Health, National Defence Medical University, Taipei City, Taiwan.
Hsiao-Ting LinGraduate Institute of Public Health, College of Public Health, National Defence Medical University, Taipei City, Taiwan.
Chih-Chien WangDepartment of Orthopedics, Tri-Service General Hospital, National Defense Medical University, Taipei City, Taiwan.
Syu-Bi LinTri-Service General Hospital Songshan Branch, Taipei City, Taiwan.
Cheng-Jung ChenDepartment of Surgery, Chiayi Branch, Taichung Veterans General Hospital, Chiayi City, Taiwan.
Mei-Jung ChenDepartment of Nursing, Tri-Service General Hospital, National Defense Medical University, Taipei City, Taiwan.
Sui-Lung SuGraduate Institute of Medical Sciences, College of Medicine, National Defence Medical University, Taipei City, Taiwan. a131419@gmail.com.

Funding

Cheng Hsin General Hospital Foundation CHNDMC-113-11201Chiayi Branch, Taichung Veterans General Hospital, Taiwan RVHCY113012Ministry of Science and Technology, Taiwan MOST111-2314-B016-011National Science and Technology Council NSTC112-2314-B-016-037Tri-Service General Hospital TSGH_D_113119Tri-Service General Hospital Songshan Branch TSGH-SS_E_113017
6 · The paper itself

Abstract

Physical activity is widely recommended to maintain muscle health in older adults, yet its effects may vary depending on genetic background. The ACTN3 R577X polymorphism leads to α-actinin-3 deficiency in XX homozygotes and may influence skeletal muscle performance. We examined the association between physical activity and muscle mass and function in 682 community-dwelling adults aged ≥ 65 years who participated in annual health examinations between 2021 and 2024. Skeletal muscle mass index was assessed using dual-energy X-ray absorptiometry, while grip strength, gait speed, and five-time chair stand performance were evaluated according to Asian Working Group for Sarcopenia criteria. Physical activity was quantified using metabolic equivalents derived from the International Physical Activity Questionnaire. No significant association was observed between ACTN3 R577X genotype and sarcopenia components. However, in women with ACTN3 XX, physical activity exceeding 441 MET-min/week was significantly associated with poorer chair stand performance (β: 4.19, 95% CI: 0.98 ~ 7.40), revealing a U-shaped relationship between physical activity and physical performance. Sex-specific physical activity thresholds may exist in older adults with the ACTN3 XX genotype, with physical activity above 441 MET-min/week being associated with poorer muscle function in women. This specific MET value is an exploratory finding, requiring more external validation.

Indexed as

ActininExerciseMuscle, SkeletalSarcopeniaAgedAged, 80 and overFemaleGenotypeHand StrengthHumansMaleSex FactorsActininACTN3 protein, humanACTN3 R577X polymorphismAgingMuscle functionPhysical activitySex differences

Identifiers

PMID42686826
PMCPMC13538621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.