ArticleNature communications2026
Self-organization of vascularized muscle from bovine embryonic stem cells.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Derivation and characterization of an embryonic‑derived muscle progenitor cell line from Atlantic salmon (Salmo salar).In vitro cellular & developmental biology. Animal · 2026Article
- Toward FGF2 reduction in cultured meat media: polyphenol salts enhance growth and differentiation of bESC aggregates.Frontiers in nutrition · 2025Article
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10 authors.
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Abstract
Cultured beef offers a promising alternative to traditional meat. While adult stem cells are commonly used as the cell source for cultured beef, their proliferation and differentiation capacities are limited. Current manufacturing processes for cultured beef steaks often require separate preparation of multiple cell types and their intricate assembly. In this study, we propose and report the co-induction of muscle, neural, and endothelial cells from bovine embryonic stem cells (ESCs), accompanied by the formation of tissue-like structures in two- and three-dimensional cultures. Bovine myocytes are induced in a stepwise manner through the induction of presomitic mesoderm (PSM) from bovine ESCs. Muscle fibers with sarcomeres appear within 15 days, displaying calcium oscillations responsive to inputs from co-induced bovine neurons. Bovine endothelial cells are also co-induced via PSM, forming uniform vessel networks inside tissues. Our serum-free, rapid co-induction protocols represent a milestone toward self-organizing beef steaks with integrated vasculature and innervation.
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