Evidence map›Paper›PMID 42686685›Full record

ArticleBone research2026

Inhibition of ERK5 activity ameliorates osteoarthritis by suppressing NLRP3 inflammasome-mediated chondrocyte pyroptosis.

Baolin Zhang, Peihang Fang, Jiahui Long, Deying Su, Hengyu Liu, Ricong Weng, Gengjia Chen, Yingtong Chen, GuanHong Chen, Zhiheng Liao and 4 more

Abstract read
In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Baolin Zhang *Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Peihang Fang *Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jiahui Long *Research Center for Translational Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Deying SuResearch Center for Translational Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Hengyu LiuDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Ricong WengDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Gengjia ChenDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yingtong ChenDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
GuanHong ChenDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhiheng LiaoDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Taifeng ZhouDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Shuqing ChenDepartment of Traditional Chinese Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. chshuq@mail.sysu.edu.cn.
Peiqiang SuDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. supq@mail.sysu.edu.cn.
Caixia XuDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. xucx3@mail.sysu.edu.cn.

Funding

Guangzhou Science and Technology Program key projects 2023B0310137National Natural Science Foundation of China (National Science Foundation of China) 82172376National Natural Science Foundation of China (National Science Foundation of China) 82572828
6 · The paper itself

Abstract

Osteoarthritis (OA) is a widespread degenerative joint disorder manifesting as chronic pain, functional impairment, and progressive disability, imposing a substantial burden on global public health. Despite extensive research, the precise molecular pathways underlying OA pathogenesis remain incompletely elucidated. Our data indicated that human OA cartilage and cartilaginous tissues from aged mice exhibited markedly elevated levels of extracellular signal-related kinase 5 (ERK5) enzyme activity. Using Col2a1-CreER

Indexed as

ChondrocytesInflammasomesMitogen-Activated Protein Kinase 7NLR Family, Pyrin Domain-Containing 3 ProteinOsteoarthritisPyroptosisAnimalsHumansMaleMiceMice, Inbred C57BLInflammasomesMitogen-Activated Protein Kinase 7NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouse

Identifiers

PMID42686685
PMCPMC13538362

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.