Evidence map›Paper›PMID 42686580›Full record

Trial reportEndocrine journal2026

Study of weight loss intervention to find an effective strategy for obesity management and the TARGET of weight loss amount for reducing health disorders (SLIM-TARGET): a randomized controlled trial.

Masaya Koshizaka, Hidetaka Yokoh, Ko Ishikawa, Aiko Hayashi, Yukari Maeda, Jin Kumagai, Kenji Takeda, Hiyori Kaneko, Tomohiro Ohno, Hiraku Ono and 46 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Endocrine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Masaya KoshizakaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0001-7374-9993
Hidetaka YokohDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0002-6784-3243
Ko IshikawaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0001-5788-2217
Aiko HayashiDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0001-8473-0163
Yukari MaedaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Jin KumagaiDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0002-9305-0423
Kenji TakedaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0001-8323-2488
Hiyori KanekoDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0003-2897-2728
Tomohiro OhnoDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Hiraku OnoDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0002-3550-9339
Yusuke HirotaDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID http://orcid.org/0000-0002-0878-9785
Takayoshi SasakoDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID http://orcid.org/0000-0002-7644-309X
Takashi KatoDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID http://orcid.org/0009-0007-6621-7885
Kengo MiyoshiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID http://orcid.org/0009-0001-1735-2075
Toshimasa YamauchiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID http://orcid.org/0000-0003-4827-6404
Hirotaka WatanabeDepartment of Metabolic Medicine, The University of Osaka Graduate School of Medicine, Osaka 565-0871, Japan.
Takaaki SakaueDepartment of Metabolic Medicine, The University of Osaka Graduate School of Medicine, Osaka 565-0871, Japan.
Mitsuyoshi TakaharaDepartment of Metabolic Medicine, The University of Osaka Graduate School of Medicine, Osaka 565-0871, Japan.ORCID http://orcid.org/0000-0001-5105-041X
Iichiro ShimomuraDepartment of Metabolic Medicine, The University of Osaka Graduate School of Medicine, Osaka 565-0871, Japan.ORCID http://orcid.org/0000-0002-0851-9603
Atsuhito SaikiCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba 285-0841, Japan.ORCID http://orcid.org/0000-0003-4009-9386
Ichiro TatsunoCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba 285-0841, Japan.ORCID http://orcid.org/0000-0002-7200-7952
Kazuhisa TakahashiDepartment of Medicine II, Kansai Medical University, Osaka 573-1010, Japan.
Satoshi KuroseHealth Science Center, Kansai Medical University, Osaka 573-1010, Japan.ORCID http://orcid.org/0000-0001-8469-0333
Yutaka KimuraHealth Science Center, Kansai Medical University, Osaka 573-1010, Japan.ORCID http://orcid.org/0000-0002-9607-0980
Takeshi OnoueDepartment of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Aichi 466-8550, Japan.ORCID http://orcid.org/0000-0002-8589-9937
Tomoko HandaDepartment of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Aichi 466-8550, Japan.ORCID http://orcid.org/0000-0003-3729-9512
Hiroshi ArimaDepartment of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Aichi 466-8550, Japan.ORCID http://orcid.org/0000-0003-3746-1997
Jun EguchiDepartment of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.ORCID http://orcid.org/0000-0003-2215-7343
Jun WadaDepartment of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.ORCID http://orcid.org/0000-0003-1468-5170
Aika MiyaDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido 060-8638, Japan.ORCID http://orcid.org/0000-0002-3313-6946
Toru KusakabeDepartment of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan.ORCID http://orcid.org/0000-0001-8644-3539
Noriko Satoh-AsaharaDepartment of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan.ORCID http://orcid.org/0000-0002-8645-3144
Junichiro IrieDepartment of Medicine II, Kansai Medical University, Osaka 573-1010, Japan.ORCID http://orcid.org/0000-0003-2662-4121
Nobuko Yamada-GotoDepartment of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Tokyo 160-8582, Japan.ORCID http://orcid.org/0000-0002-5641-921X
Masahiro KondoDepartment of Biostatistics, Keio University School of Medicine, Tokyo 160-8582, Japan.ORCID http://orcid.org/0000-0003-4647-3746
Kengo NagashimaBiostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo 160-8582, Japan.ORCID http://orcid.org/0000-0003-4529-9045
Yasunori SatoDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo 160-8582, Japan.ORCID http://orcid.org/0000-0002-7189-5126
Shigeru MiyazakiCenter for Comprehensive Health Check and Promotion, Japan Anti-Tuberculosis Association, Tokyo 101-8372, Japan.
Hiroko YamamotoDiabetes and Endocrinology, Matsuyama Shimin Hospital, Ehime 790-0067, Japan.
Yoshie KondoEndocrinology and Metabolism, Shizuoka City Shizuoka Hospital, Shizuoka 420-8630, Japan.
Masako WakiEndocrinology and Metabolism, Shizuoka City Shizuoka Hospital, Shizuoka 420-8630, Japan.ORCID http://orcid.org/0000-0001-7721-7302
Hiroaki UenoDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.ORCID http://orcid.org/0000-0003-4947-594X
Masamitsu NakazatoDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.ORCID http://orcid.org/0000-0002-6511-1049
Yoshiro NakayamaSecond Department of Internal Medicine (Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology), Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0213, Japan.
Hiroaki MasuzakiSecond Department of Internal Medicine (Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology), Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0213, Japan.ORCID http://orcid.org/0000-0002-2445-1047
Takayuki MasakiGlobal Oita Medical Advanced Research Center for Health, Oita University, Oita 879-5593, Japan.ORCID http://orcid.org/0000-0002-2378-849X
Masayuki OhtaGlobal Oita Medical Advanced Research Center for Health, Oita University, Oita 879-5593, Japan.ORCID http://orcid.org/0009-0004-3344-5249
Masahiro NishiFirst Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.
Makito TanabeDepartment of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Ryuya IwamotoDepartment of Endocrinology and Metabolism, Sumitomo Hospital, Osaka 530-0005, Japan.
Takafumi SenokuchiDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.ORCID http://orcid.org/0000-0001-7423-0878
Takuro HorikoshiDiagnostic Radiology and Radiation Oncology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0003-1433-2914
Kazuyo TsushitaFaculty of Nutrition, Japan Nutrition University, Saitama 350-0288, Japan.ORCID http://orcid.org/0000-0002-5755-9345
Takashi KadowakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID http://orcid.org/0000-0002-5428-3582
Koutaro YokoteDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.ORCID http://orcid.org/0000-0003-3033-4813
SLIM-TARGET study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This randomized controlled study aimed to clarify weight loss targets for improving obesity-related disorders in individuals with overweight or obesity. A total of 294 participants with six obesity-related conditions were assigned to either a standard or intensive treatment group, with 12-month weight loss targets of ≥3% and ≥7%, respectively. The standard group followed the Japanese Guidelines for the Management of Obesity Disease 2016. The intensive group received frequent nutritional guidance, enhanced diet and exercise therapy, and additional pharmacotherapy. The primary outcome was weight loss and improvement in at least two obesity-related disorders at 12 months. Secondary outcomes included remission of health disorders, improvement in at least one health disorder, and visceral fat reduction. At 12 months, the weight loss was -2.5% in the intensive group and -1.7% in the standard group, with no significant difference in the primary outcome. However, remission of health disorders was achieved in 16.9% of the intensive group compared with 6.2% of the standard group (adjusted odds ratio 3.079; 95% CI 1.075-8.823; p = 0.036). Visceral fat reduction was greater in the intensive group (-20.46 cm

Indexed as

ObesityObesity ManagementWeight LossWeight Reduction ProgramsAdultAnti-Obesity AgentsDiet, ReducingExercise TherapyFemaleHumansIntra-Abdominal FatMaleMiddle AgedOverweightTreatment OutcomeAnti-Obesity AgentsHypertensionObesity-related health disorderRemissionVisceral fatWeight loss

Identifiers

PMID42686580
PMCPMC13755635

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.