ArticleCellular and molecular gastroenterology and hepatology2026
Control of Intestinal Type 3 Immunity by the Unfolded Protein Response Sensor Inositol-Requiring Enzyme 1α in Antigen-Presenting Cells.
Article in Cellular and molecular gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
BACKGROUND &
aimsThe unfolded protein response is an essential cellular program maintaining intestinal homeostasis by acting on several cell types. However, whether the unfolded protein response sensor inositol-requiring enzyme 1α acts on dendritic cells and other antigen-presenting cells for shaping intestinal immunity remains poorly defined.
methodsHere, we dissect the role of the endoribonuclease domain of the unfolded protein response sensor inositol-requiring enzyme 1α in intestinal CD11c
resultsWe identify robust inositol-requiring enzyme 1α endoribonuclease activity in intestinal conventional dendritic cell subsets, dendritic cells associated with crypto patches and isolated lymphoid follicles, and macrophages, independently of microbial signals. Targeted ablation of inositol-requiring enzyme 1α endoribonuclease in the intestinal CD11c
conclusionsCollectively, our findings uncover inositol-requiring enzyme 1α endoribonuclease in intestinal CD11c
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