Evidence map›Paper›PMID 42685801›Full record

ArticleKorean journal of anesthesiology2026

Analgesic mechanism of Panaphix in spinal nerve-ligated rats: involvement of microglial inflammatory cytokines.

Myong-Hwan Karm, Hyun-Jung Kwon, Doo-Hwan Kim, Jun-Seok Lee, Minsu Han, Eun Ha Kim, Chan-Sik Kim, Jin-Woo Shin, Seong-Soo Choi

Abstract read
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In one paragraph

Article in Korean journal of anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Myong-Hwan KarmDepartment of Dental Anesthesiology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.
Hyun-Jung KwonDepartment of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Doo-Hwan KimWell Spine Clinic, Seoul, Korea.
Jun-Seok LeeDepartment of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Minsu HanDepartment of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Eun Ha KimDepartment of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Chan-Sik KimDepartment of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jin-Woo ShinDepartment of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Seong-Soo ChoiDepartment of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. choiss@amc.seoul.kr.

Funding

Komipharm International Co., Ltd
6 · The paper itself

Abstract

backgroundNeuropathic pain, a chronic and debilitating condition caused by damage to the nervous system, remains challenging to treat due to its complex pathophysiology and resistance to analgesics. This study investigated the analgesic effects of Panaphix (PAX-1), a novel pharmacological agent, in a rat model of neuropathic pain induced by spinal nerve ligation (SNL).

methodsMale Sprague-Dawley rats underwent SNL to induce neuropathic pain. PAX-1 (0.1, 1, or 10 mg/kg) or vehicle was administered orally once daily for seven consecutive days starting on postoperative day 8. Mechanical allodynia was evaluated using the von Frey filament test, and the dorsal root ganglia were analyzed using an enzyme-linked immunosorbent assay and immunofluorescence to evaluate tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression levels.

resultsPAX-1 significantly alleviated mechanical allodynia induced by SNL in a dose-dependent manner, and 1 mg/kg was selected as the optimal dose for subsequent analyses. PAX-1 markedly reduced IL-1β expression in microglia and partially decreased TNF-α immunoreactivity within the dorsal root ganglion, while showing minimal effects on the expression of astrocytic cytokines.

conclusionsPAX-1 demonstrated potent anti-allodynic and anti-inflammatory effects in an SNL-induced neuropathic pain model. These findings indicate that PAX-1 may exert analgesic effects primarily through modulation of IL-1β-mediated microglial activation, suggesting its therapeutic potential for neuropathic pain management.

Indexed as

AnalgesicsCytokinesInflammation MediatorsMicrogliaNeuralgiaSpinal NervesAnimalsDisease Models, AnimalDose-Response Relationship, DrugHyperalgesiaInterleukin-1betaLigationMaleRatsRats, Sprague-DawleyTumor Necrosis Factor-alphaAnalgesicsCytokinesInflammation MediatorsInterleukin-1betaTumor Necrosis Factor-alphaArseniteDorsal root ganglionInterleukin-1βLigationMechanical allodyniaMicrogliaNeuropathic pain

Identifiers

PMID42685801
PMCPMC13624826

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.