Advances in chemoenzymatic synthesis of glycosaminoglycans and proteoglycans.

Shahnaz Akhtar Nishat, Xuefei Huang

Abstract readReview

In one paragraph

Review in Current opinion in chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shahnaz Akhtar NishatDepartment of Chemistry, Michigan State University, East Lansing, MI, 48824, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824, United States.

Xuefei HuangDepartment of Chemistry, Michigan State University, East Lansing, MI, 48824, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824, United States; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, United States. Electronic address: huangxu2@msu.edu.

Funding

Syntheses of homogeneous proteoglycan like glycopeptide and glycoprotein libraries for microarray studiesR35GM158263 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Xuefei Huang · 2025 to 2026

$810k

NIGMS NIH HHS R35 GM158263

6 · The paper itself

Abstract

Proteoglycans (PGs) are intricate macromolecules decorated with linear polysulfated glycosaminoglycans (GAGs) that play critical roles in orchestrating a wide range of physiological and pathological events. Advances in the utilization of recombinant enzymes and biosynthetic pathways have expedited the production of defined and homogeneous GAGs, helping overcome traditional barriers of chemical synthesis. Furthermore, the synthesis of GAG chains has been increasingly integrated with other critical structural elements, most notably the core proteins. Robust synthetic methodologies toward well-defined GAGs and entire PG structures are critical because there is a lack of comprehensive structure-function data that addresses the PG architecture as a unified glycoconjugate. The construction of homogeneous PG is a formidable and rapidly evolving frontier in chemical biology, and the latest developments in this arena are summarized in this review.

Indexed as

GlycosaminoglycansProteoglycansAnimalsHumansGlycosaminoglycansProteoglycans

Identifiers

PMID42685652

DOI10.1016/j.cbpa.2026.102753

PMCPMC13561155

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.