Restoring pre-osteoarthritis cartilage matrix integrity via Col9 mRNA halts osteoarthritis progression.

Jun Zhou, Jingrui Hu, Erica Yada, Jingxiao Zhong, Yuki Terai, C Peter Winlove, Junning Chen, Yo Shibata, Keiji Itaka

Abstract read

In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Divergent trajectories of structural accrual and matrix-level mechanical properties during alveolar bone maturation.Calcified tissue international · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun ZhouClinical Biotechnology Team, Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0000-0002-3163-0887

Jingrui HuBiomedical Engineering, Department of Engineering, Faculty of Environment, Science and Economy, University of Exeter, Exeter EX4 4RN, UK.ORCID 0000-0002-2786-7507

Erica YadaInstitute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan.

Jingxiao ZhongDepartment of Biomaterials and Engineering, Showa Medical University Graduate School of Dentistry, Shinagawa-ku, Tokyo 142-8555, Japan.ORCID 0000-0002-6380-0641

Yuki TeraiInstitute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan.ORCID 0000-0002-0391-5367

C Peter WinloveBiophysics, Faculty of Environment, Science and Economy, University of Exeter, Exeter, UK.

Junning ChenBiomedical Engineering, Department of Engineering, Faculty of Environment, Science and Economy, University of Exeter, Exeter EX4 4RN, UK.ORCID 0000-0001-7121-0994

Yo ShibataDepartment of Biomaterials and Engineering, Showa Medical University Graduate School of Dentistry, Shinagawa-ku, Tokyo 142-8555, Japan.ORCID 0000-0002-1876-3298

Keiji ItakaClinical Biotechnology Team, Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0000-0001-5132-5356

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by the progressive breakdown of cartilage. Here, we sought to define a pre-osteoarthritis (pre-OA) state using nanoindentation-based mechanical testing and evaluation of collagen organization in cartilage matrix. The reductions in elastic modulus and impaired viscoelasticity preceded any overt histological degeneration. This mechanical dysfunction was primarily driven by early disorganization of type II collagen, occurring before substantial depletion of cartilage components. We subsequently identified type IX collagen (Col IX), which played a critical role at the pre-OA stage. Intra-articular administration of

Indexed as

Cartilage, ArticularCollagen Type IXExtracellular MatrixOsteoarthritisRNA, MessengerAnimalsCollagen Type IIDisease Models, AnimalDisease ProgressionMaleRatsCollagen Type IICollagen Type IXRNA, Messenger

Identifiers

PMID42685225

DOI10.1126/sciadv.aef9739

PMCPMC13537250

What OpenQuestion holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.