Evidence map›Paper›PMID 42685221›Full record

ArticleScience advances2026

Combinatorial action of regulatory systems generates colistin heteroresistance.

Jacob E Choby, Emily K Crispell, Muqing Ma, Linda M Vu, Mary-Kate Key, Robert K Ernst, Minsu Kim, David S Weiss

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jacob E ChobyEmory Antibiotic Resistance Center, Atlanta, GA 30322, USA.ORCID 0000-0002-3077-0730
Emily K CrispellEmory Antibiotic Resistance Center, Atlanta, GA 30322, USA.
Muqing MaEmory Antibiotic Resistance Center, Atlanta, GA 30322, USA.ORCID 0009-0001-1369-2689
Linda M VuDepartment of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, MD 21201, USA.ORCID 0009-0006-8004-3175
Mary-Kate KeyEmory Antibiotic Resistance Center, Atlanta, GA 30322, USA.ORCID 0009-0003-7551-9616
Robert K ErnstDepartment of Microbial Pathogenesis, University of Maryland-Baltimore, Baltimore, MD 21201, USA.ORCID 0000-0001-5016-8694
Minsu KimEmory Antibiotic Resistance Center, Atlanta, GA 30322, USA.ORCID 0000-0003-1594-4971
David S WeissEmory Antibiotic Resistance Center, Atlanta, GA 30322, USA.ORCID 0000-0003-0980-7866

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Single Cell Analysis Core (Core C)U19AI158080 · NIAID · EMORY UNIVERSITY · PI LEVIN, BRUCE RICHARD, WEISS, DAVID S · 2021 to 2025
$10.9M
Heteroresistance Interdisciplinary Research Unit: Quantitative Analysis and Single-Cell Microscopy Core (Core C)P01AI197193 · NIAID · EMORY UNIVERSITY · PI DAVID S WEISS · 2026 to 2026
$2.9M
Research Training in Translational Gastroenterology and HepatologyT32DK108735 · NIDDK · EMORY UNIVERSITY · PI SUBRA KUGATHASAN · 2016 to 2026
$2.6M
Mechanisms of phenotypic antibiotic resistance in Gram-negative bacteriaR01AI141883 · NIAID · EMORY UNIVERSITY · PI WEISS, DAVID S · 2018 to 2022
$2.2M
NIAID NIH HHS P01 AI197193NIAID NIH HHS R01 AI141883NIAID NIH HHS U19 AI158080NIDDK NIH HHS T32 DK108735NIH HHS P51 OD011132
6 · The paper itself

Abstract

The mechanism by which phenotypic heterogeneity is generated within a bacterial population and leads to colistin heteroresistance has been unclear. Heteroresistance is a form of antibiotic resistance in which a minor subpopulation of resistant cells coexists with a majority susceptible population. Colistin heteroresistance is common among

Indexed as

Anti-Bacterial AgentsColistinDrug Resistance, BacterialBacterial ProteinsGene Expression Regulation, BacterialMicrobial Sensitivity TestsSigma FactorAnti-Bacterial AgentsBacterial ProteinsColistinSigma Factor

Identifiers

PMID42685221
PMCPMC13537233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.