In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Liang HuDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.ORCID 0000-0003-4402-1930 Niousha AhmariDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
Abby SchaeperDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.ORCID 0009-0009-0445-3027 Jay PundavelaDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.ORCID 0000-0003-2861-4736 Mi-Ok KimDepartment of Epidemiology and Biostatistics, UCSF, 1450 3rd Street, San Francisco, CA 94143, USA.ORCID 0000-0002-7712-3653 Jianqiang WuDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.ORCID 0000-0002-4239-5659 Julia BrunmairBoehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer Gasse 5-11, A-1120 Vienna, Austria.ORCID 0000-0002-7702-3468 Özlem Yüce PetronczkiBoehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer Gasse 5-11, A-1120 Vienna, Austria.
Nancy RatnerDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.ORCID 0000-0001-5030-9354 Funding
T32 Cincinnati Pediatric Clinical Pharmacology Training ProgramT32HD069054 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI TRACY A GLAUSER, Sonya C Tang Girdwood · 2011 to 2026
$3.0MIdentification of Novel Pathways Causing NF1-Driven Schwann Cell TumorsR01NS120892 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI NANCY RATNER · 2022 to 2026
$2.5MNICHD NIH HHS T32 HD069054NINDS NIH HHS R01 NS120892
6 · The paper itselfAbstract
Patients with neurofibromatosis type 1 develop Schwann cell tumors called neurofibromas that arise within peripheral nerves, driven by loss of neurofibromin and consequent increased RAS/RAF/MEK signaling. MEK inhibitors achieve partial responses for benign neurofibromas but are limited by toxicity and incomplete efficacy, necessitating alternative approaches. Using the
Indexed as
Neurofibroma, PlexiformProto-Oncogene Proteins p21(ras)AnimalsCell ProliferationDisease Models, AnimalHumansMiceNeurofibromatosis 1Neurofibromin 1Tumor MicroenvironmentHras protein, mouseNeurofibromin 1Proto-Oncogene Proteins p21(ras)
Identifiers
PMID42685218
PMCPMC13537243
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