Evidence map›Paper›PMID 42685214›Full record

ArticleScience advances2026

A single-point mutation in TRPA1 drives heat resilience in oviparous embryos.

Tian-Yu Feng, Wenqi Dong, Dong Zheng, Lei Han, Jiatong Cheng, Xuanye Wu, Xiancui Lu, Shilong Yang, Wei-Guo Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tian-Yu FengState Key Laboratory of Wetland Conservation and Restoration, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, and Institute of Eco-Chongming, School of Life Sciences, Fudan University, Shanghai 200438, China.ORCID 0009-0000-5763-044X
Wenqi DongCollege of Wildlife and Protected Areas, Northeast Forestry University, Harbin 150040, China.ORCID 0009-0001-5226-648X
Dong ZhengCollege of Wildlife and Protected Areas, Northeast Forestry University, Harbin 150040, China.ORCID 0000-0002-1668-0843
Lei HanCollege of Wildlife and Protected Areas, Northeast Forestry University, Harbin 150040, China.
Jiatong ChengCollege of Wildlife and Protected Areas, Northeast Forestry University, Harbin 150040, China.
Xuanye WuCollege of Wildlife and Protected Areas, Northeast Forestry University, Harbin 150040, China.
Xiancui LuCollege of Wildlife and Protected Areas, Northeast Forestry University, Harbin 150040, China.ORCID 0000-0002-9539-852X
Shilong YangCollege of Wildlife and Protected Areas, Northeast Forestry University, Harbin 150040, China.ORCID 0000-0002-2618-1837
Wei-Guo DuState Key Laboratory of Wetland Conservation and Restoration, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, and Institute of Eco-Chongming, School of Life Sciences, Fudan University, Shanghai 200438, China.ORCID 0000-0002-1868-5664

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular basis for species-specific thermal adaptation in vertebrate sensory systems is not well understood. We show that a single-amino-acid change in the pore domain of ion channel transient receptor potential ankyrin 1 (TRPA1) during the synapsid-diapsid split rewired its heat sensitivity. Many oviparous vertebrates retaining the ancestral residue display TRPA1 heat activation, protecting embryonic development under high temperatures, whereas selection for an aspartate in mammals reduced thermal responsiveness. Blocking heat-activated TRPA1 in oviparous embryos impaired dorsal-root-ganglion axon growth, disrupted myelination, and caused limb weakness at hatching. Mechanistically, TRPA1-mediated Ca

Indexed as

Point MutationTRPA1 Cation ChannelAnimalsCalciumHot TemperatureCalciumTRPA1 Cation Channel

Identifiers

PMID42685214
PMCPMC13537265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.