ArticleScience advances2026
A male-biased hypothalamic circuit modulates postmating sleep suppression in mice.
Jin Zhao, Linhao Jiang, Qian Zhang, Shajin Huang, Xueping Gao, Minghui Song, Xue Lu, Siwen Pan, Xi Zha, Lei Jin and 4 more
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In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Jin ZhaoInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0008-9471-1271 Linhao JiangDepartment of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0009-0007-7850-4240 Qian ZhangInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
Shajin HuangInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
Xueping GaoLingang Laboratory, Shanghai 200031, China.
Minghui SongLingang Laboratory, Shanghai 200031, China.
Xue LuDepartment of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Siwen PanInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-1846-1599 Xi ZhaInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
Xiaohong XuState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.ORCID 0000-0002-2447-3529 Huateng CaoInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0001-9622-3812 Qianzi YangDepartment of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0003-2240-3356 Zhe ZhangInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-0899-8077 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Many species display mating-related sleep suppression to maximize reproductive success, yet the underlying neural mechanisms in mammals remain unclear. Here, we report that male mice exhibit delayed sleep onset and reduced sleep duration in periods following successful mating, while females are unaffected. Single-cell transcriptomics identifies a group of sleep-promoting Rxfp1-expressing neurons in the preoptic area of hypothalamus (POA
Indexed as
HypothalamusSleepAnimalsFemalegamma-Aminobutyric AcidMaleMiceNeuronsOptogeneticsPreoptic AreaSeptal NucleiSexual Behavior, AnimalSleep DurationWakefulnessgamma-Aminobutyric Acid
Identifiers
PMID42685204
PMCPMC13537264
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