Evidence map›Paper›PMID 42685200›Full record

ArticleScience advances2026

Aortic disease-linked mutations reveal unexpected convergent allosteric mechanisms of protein kinase G misregulation.

Karla Martinez Pomier, Leopold Jahn, Bryan VanSchouwen, Hebatallah Mohamed, Madoka Akimoto, Sun Woo Jung, Daniela Bertinetti, Johannes Mehringer, Leonardo Della Libera, Friederike Cuello and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karla Martinez PomierDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-1411-3383
Leopold JahnInstitute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.ORCID 0000-0001-7298-262X
Bryan VanSchouwenDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Hebatallah MohamedDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-2272-2173
Madoka AkimotoDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-0510-5613
Sun Woo JungDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Daniela BertinettiInstitute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.ORCID 0000-0003-1150-3765
Johannes MehringerKurt Schwabe Institute for Sensor Technologies, Waldheim, Germany.ORCID 0000-0003-2650-1850
Leonardo Della LiberaDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-6475-2186
Friederike CuelloInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-1612-1715
Friedrich W HerbergInstitute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.ORCID 0000-0001-7117-7653
Giuseppe MelaciniDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-1164-2853

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thoracic aortic aneurysms and dissections (TAAD) are life-threatening conditions linked to gain-of-function mutations in cGMP-dependent protein kinase I (PKG I), a central regulator of vascular smooth muscle signaling. Among these, substitutions at Val

Indexed as

Aortic Aneurysm, ThoracicAortic DissectionCyclic GMP-Dependent Protein KinasesCyclic GMP-Dependent Protein Kinase Type IMutationAllosteric RegulationCatalytic DomainCyclic GMPDissection, Thoracic AortaHumansMolecular Dynamics SimulationProtein BindingProtein ConformationSignal TransductionCyclic GMPCyclic GMP-Dependent Protein KinasesCyclic GMP-Dependent Protein Kinase Type I

Identifiers

PMID42685200
PMCPMC13537252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.