SynthesisPloS one2026
Association between Eubacterium saphenum and periodontitis: A systematic review.
Synthesis in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAlthough established periodontal pathobionts are frequently detected, their presence alone does not fully explain variations in disease severity, highlighting the need to identify additional microbial contributors. This systematic review evaluates the available evidence on the association between Eubacterium saphenum and the severity of periodontitis.
methodsThe review was conducted in accordance with the PRISMA 2020 framework and registered in PROSPERO (CRD420251273182). Observational studies involving systemically healthy adults were included that compared individuals with periodontitis and periodontal health, reporting detection and/or relative abundance of E. saphenum in saliva and/or subgingival biofilm samples. Study quality was appraised using the AXIS tool, and certainty of evidence was assessed using the GRADE framework.
resultsEight observational studies (304 healthy controls vs. 510 periodontitis cases) from Asia, Europe, and the Americas met the inclusion criteria. Across multiple detection platforms, E. saphenum showed a qualitatively similar direction of association, being more frequently detected and/or present at higher relative abundance in periodontitis than in periodontal health controls. Among studies applying the 2018 periodontal classification system and reporting stage-specific analyses, higher detection or enrichment of E. saphenum was generally observed in advanced disease (stages III-IV). The certainty of evidence was rated as low owing to the observational and predominantly cross-sectional design of the evidence, methodological heterogeneity, and lack of temporality.
conclusionsLow-certainty evidence suggests a positive directional association between E. saphenum and periodontitis, particularly in advanced Stage III-IV disease. However, longitudinal, interventional, and mechanistic studies are required to clarify temporality and determine whether E. saphenum contributes functionally to periodontal dysbiosis or primarily represents a marker of established disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.