ArticlePloS one2026
Presence of Dolosigranulum pigrum in the nasopharynx and its relationship with respiratory health status in paediatric population.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundRespiratory tract infections range from asymptomatic colonisation to an invasive disease. Recent studies suggest that nasopharyngeal microbiota may influence this variability. Emerging evidence points to Dolosigranulum pigrum, a nasopharyngeal commensal, as a potentially protective bacterium. This study aimed to identify variables associated with the presence of D. pigrum in the nasopharynx of children with varying respiratory health statuses.
methodsNasopharyngeal aspirates were collected from children <18 years who were asymptomatic (n = 65), had banal viral infection (n = 48), or Invasive Pneumococcal Disease (IPD) (n = 27). The presence of D. pigrum was defined as >0.1% of total sequences obtained by 16S rRNA gene sequencing. Variables included sex, breastfeeding, delivery mode, S. pneumoniae carriage, respiratory viruses and clinical features.
resultsAmong 140 children (73 males, 67 females), D. pigrum was detected in 79 (56.4%): 44/65 in the healthy group; 26/48 of viral and 9/27 IPD cases. Multivariate analysis revealed significant associations with health status and sex. Healthy children were more likely to carry D. pigrum than IPD cases (44/79 vs. 26/79; p = 0.028). Males were more frequently D. pigrum carriers than females (48/79 vs. 31/79; p = 0.033).
conclusionD. Pigrum was associated with respiratory health, being more prevalent in healthy children, and showed potential sex-related differences.
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