Evidence map›Paper›PMID 42684933›Full record

ArticleMicrobiology spectrum2026

Quantitative and molecular adjudication of BioFire FilmArray and QIAstat-Dx discordance in meningitis/encephalitis diagnostics.

Rainer Gosert, Christopher M Field, Roger Koller, Dominic C Mills, Klaudia Naegele, Maximilian Koester, Jakob Meyer, Ulrich Heininger, Tobias Derfuss, Lena Jaki and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Rainer GosertClinical Virology, University Hospital Basel, Basel, Switzerland.
Christopher M FieldLaboratory Medicine, University Hospital Basel, Basel, Switzerland.
Roger KollerInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Dominic C MillsInstitute of Medical Virology, University of Zürich, Zürich, Switzerland.ORCID 0009-0005-2261-2790
Klaudia NaegeleClinical Virology, University Hospital Basel, Basel, Switzerland.
Maximilian KoesterClinical Bacteriology/Mycology, University Hospital Basel, Basel, Switzerland.
Jakob MeyerEmergency Medicine, University Hospital Basel, Basel, Switzerland.
Ulrich HeiningerPediatric Infectious Diseases and Vaccinology, University of Basel Children's Hospital, Basel, Switzerland.
Tobias DerfussNeurology, University Hospital Basel, Basel, Switzerland.ORCID 0000-0001-8656-4250
Lena JakiClinical Virology, University Hospital Basel, Basel, Switzerland.
Stefano BassettiInternal Medicine, University Hospital Basel, Basel, Switzerland.
Reto LienhardADMED Microbiology, La Chaux-de-Fonds, Switzerland.
Antony CroxattoADMED Microbiology, La Chaux-de-Fonds, Switzerland.
Roland BingisserEmergency Medicine, University Hospital Basel, Basel, Switzerland.ORCID 0000-0001-8223-9792
Christian H NickelEmergency Medicine, University Hospital Basel, Basel, Switzerland.
Pascal BittelInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Guido BloembergInstitute of Medical Virology, University of Zürich, Zürich, Switzerland.
Sarah Tschudin-SutterDivision of Infectious Diseases, University Hospital Basel, Basel, Switzerland.ORCID 0000-0003-4875-5368
Nina KhannaDivision of Infectious Diseases, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-2642-419X
Peter M Keller *Clinical Bacteriology/Mycology, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-2890-5384
Karoline Leuzinger *Clinical Virology, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-5654-9356

Funding

University Hospital Basel
6 · The paper itself

Abstract

Syndromic multiplex panels enable rapid cerebrospinal fluid (CSF) diagnosis of meningitis and encephalitis, but clinically relevant inter-platform discordance persists, and its analytical basis remains incompletely understood. In this retrospective multicenter study, 182 residual CSF specimens from 182 patients at 4 Swiss tertiary-care centers and 10 external quality assessment samples were tested centrally by the QIAstat-Dx Meningitis/Encephalitis panel and compared with routine BioFire FilmArray results. Discordant results were adjudicated using pathogen-specific quantitative laboratory-developed tests (LDTs) calibrated to external standards, and enterovirus-positive specimens underwent molecular typing. Among 182 clinical CSF specimens, concordance was 87.9% across shared targets. Complete agreement was observed for herpes simplex virus type 2,

Indexed as

EncephalitisMeningitisMolecular Diagnostic TechniquesMultiplex Polymerase Chain ReactionBacteriaCerebrospinal FluidEnterovirusHumansRetrospective StudiesSensitivity and SpecificitySwitzerlandVirusescerebrospinal fluidenterovirusFilmArraymeningitis/encephalitis panelQIAstat-Dxsyndromic panel testing

Identifiers

PMID42684933
PMCPMC13689469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.