Evidence map›Paper›PMID 42684844›Full record

ArticleMolecular biology of the cell2026

Organelle partitioning in the multi-budding yeast

Alison C E Wirshing, Michelle Yan, Daniel J Lew

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Organelle scaling over a 100-fold cell size range.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Alison C E WirshingDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Michelle YanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Daniel J LewDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular organelle content is fairly constant within a given cell type. This is accomplished in part by ensuring equitable organelle partitioning during division. Much of our understanding of organelle inheritance has come from investigating cells that divide in half, producing two daughter cells. However, more elaborate division strategies that give rise to multiple daughters are not uncommon in nature. Here, we present the first characterization of organelle inheritance in a fungus that can grow by multi-budding, producing up to 20 daughter cells in a single cell cycle. We find that some organelles (mitochondria and ER) are evenly delivered to all growing buds, while others (vacuole and peroxisomes) are more variably inherited. We discuss the implications of even and uneven inheritance for this polyextremotolerant fungus capable of growing in dynamic and diverse environments.

Indexed as

AscomycotaOrganellesCell DivisionEndoplasmic ReticulumMitochondriaPeroxisomesVacuoles

Identifiers

PMID42684844
PMCPMC13637732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.