Evidence map›Paper›PMID 42684683›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β-Adrenoceptor Stimulation.

Florentina Pluteanu, Alexander Heinick, Manuel Domnik-Lehnert, Frank U Müller, Christina Hermes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Florentina PluteanuDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania.ORCID https://orcid.org/0000-0003-0743-0129
Alexander HeinickInstitute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.
Manuel Domnik-LehnertInstitute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.
Frank U MüllerInstitute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.
Christina HermesInstitute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.

Funding

Deutsche Forschungsgemeinschaft (DFG) Mu1376/11-3IZKF Muenster Mu1/011/17
6 · The paper itself

Abstract

Annexin A4 (A4) is a negative modulator of adenylyl cyclase type 5 (AC5) with increased expression in failing human hearts. Here, we investigated whether A4 deficiency contributes to cardiac electrical and structural remodeling induced by chronic stimulation of β-adrenergic receptors (βAR). A4-deficient mice (gene trapped, GT) and wild-type (WT) were infused for 7 days with isoprenaline (ISO) or NaCl as control. Myocytes of ISO-treated GT (GT

Indexed as

Heart VentriclesMyocytes, CardiacReceptors, Adrenergic, betaVentricular RemodelingAction PotentialsAdrenergic beta-AgonistsAnimalsIsoproterenolMaleMiceMice, KnockoutSignal TransductionAdrenergic beta-AgonistsIsoproterenolReceptors, Adrenergic, betaaction potentialannexin A4cardiomyocytesion channelsisoprenalineventricular hypertrophy

Identifiers

PMID42684683
PMCPMC13537368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.