Evidence map›Paper›PMID 42684632›Full record

ArticleGeroScience2026

Intermediate leucine catabolism is associated with longevity and sustained reproduction in grasshoppers.

Kerri Conklin, Haley Peters, Morgan Tomlinson, Rebekah Sein, Jeremiah Kaplan, Gabriel Nealy, Alicia Horton, Hayat Husein, Isabella Ihemis, Connor Clark and 2 more

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kerri ConklinDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Haley PetersDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Morgan TomlinsonDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Rebekah SeinDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Jeremiah KaplanDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Gabriel NealyDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Alicia HortonDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Hayat HuseinDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Isabella IhemisDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Connor ClarkDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA.
Marshall D McCueSable Systems International, 3840 N Commerce St #8104, North Las Vegas, NV, 89032, USA.
John HatleDepartment of Biology, University of North Florida, 1 UNF Drive, Jacksonville, FL, 32224, USA. jhatle@unf.edu.ORCID http://orcid.org/0000-0002-9075-7116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary isoleucine restriction improves metabolic health and lifespan in animal models. It is hypothesized that shifts in branched-chain amino acid catabolism drive longevity. We investigated dietary isoleucine restriction on organismal branched-chain amino acid catabolism and its association with longevity and reproduction. In two main experiments, adult female Lubber grasshoppers were assigned to a high-quality diet (Bal ile) or diets with two levels of isoleucine content (moderate isoleucine restriction [Mod ile-R] or severe isoleucine restriction [Sev ile-R]). In Experiment 2, we used a low-energy (Low Lett) group as a positive control for catabolism. In Experiment 3, we used an ad libitum lettuce (Ad Lib Lett) control to show the reproduction-longevity trade-off. Nutrient-specific, organismal catabolism was measured by tracking

Indexed as

Branched-chain amino acid catabolismIsoleucine restrictionLeucine catabolismLifespan extensionReproduction-longevity trade-offValine catabolism

Identifiers

PMID42684632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.