Evidence map›Paper›PMID 42684456›Full record

ArticleThe Journal of membrane biology2026

Targeting of Acid Sphingomyelinase, a Lysosomal Membrane Protein, Using Apolipoprotein E3-containing Nanodiscs.

Vidya Metkar, Vernon Gil Benedicto, Jingyuan Zheng, Angela M Zivkovic, Nestor D Plascencia, Thomas Gredig, Vasanthy Narayanaswami

Abstract read
In one paragraph

Article in The Journal of membrane biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vidya MetkarDepartment of Chemistry and Biochemistry, California State University, Long Beach, 1250 Bellflower Blvd, Long Beach, CA, 90840, USA.
Vernon Gil BenedictoDepartment of Chemistry and Biochemistry, California State University, Long Beach, 1250 Bellflower Blvd, Long Beach, CA, 90840, USA.
Jingyuan ZhengDepartment of Nutrition, University of California, Davis, CA, 95616, USA.
Angela M ZivkovicDepartment of Nutrition, University of California, Davis, CA, 95616, USA.
Nestor D PlascenciaDepartment of Physics and Astronomy, California State University, Long Beach, Long Beach, CA, 90840, USA.
Thomas GredigDepartment of Physics and Astronomy, California State University, Long Beach, Long Beach, CA, 90840, USA.
Vasanthy NarayanaswamiDepartment of Chemistry and Biochemistry, California State University, Long Beach, 1250 Bellflower Blvd, Long Beach, CA, 90840, USA. vas.narayanaswami@csulb.edu.ORCID https://orcid.org/0000-0001-7088-4057

Funding

Transendothelial transport mediated modulations to the High Density LipoproteinSC3GM105561 · NIGMS · CALIFORNIA STATE UNIVERSITY LONG BEACH · PI NARAYANASWAMI, VASANTHY · 2013 to 2021
$876k
Role Of Apolipoprotein E In Maintaining the Blood Brain Barrier IntegrityR16NS140312 · NINDS · CALIFORNIA STATE UNIVERSITY LONG BEACH · PI VASANTHY NARAYANASWAMI · 2024 to 2026
$443k
National Science Foundation 2425133NIGMS NIH HHS SC3 GM105561NIH HHS GM105561, NS140312NINDS NIH HHS R16 NS140312
6 · The paper itself

Abstract

We developed a nanodisc (ND)-based platform with recombinant acid sphingomyelinase (ASM) embedded in a bilayer of phospholipids that are circumscribed by apolipoprotein E3 (apoE3) for targeted delivery to lysosomes. We designed a fusion protein comprising essential catalytic segments of ASM with a transmembrane helix at one end (TM-ASM

Indexed as

LysosomesNanostructuresSphingomyelin PhosphodiesteraseHumansLipid BilayersRecombinant Fusion ProteinsSphingomyelinsLipid BilayersRecombinant Fusion ProteinsSphingomyelin PhosphodiesteraseSphingomyelinsAcid sphingomyelinaseEnzyme Replacement TherapyLysosomal Membrane Protein; Apolipoprotein ENanodiscsSphingomyelin

Identifiers

PMID42684456
PMCPMC13538249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.