SynthesisSurgical and radiologic anatomy : SRA2026
Anatomical determinants of sphenoid sinus volume: insights from a meta-analysis of observational studies.
Synthesis in Surgical and radiologic anatomy : SRA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundThe sphenoid sinus is one of the most anatomically variable structures of the skull base. Its volume may be influenced by pneumatization patterns, septation, and the relationship to adjacent neurovascular structures, notably the internal carotid artery (ICA) and optic nerve (ON).
objectiveThe systematic review and meta-analysis assessed the influence of sphenoid sinus volume on pneumatization patterns, neurovascular protrusions, and accessory septa, as well as demographic variables such as sex and age.
methodsThis systematic review and meta-analysis were conducted per PRISMA guidelines. Eligible studies involving anatomical and radiological studies of sphenoid sinus volume were included. Subgroup analyses were performed based on pneumatization type (conchal, presellar, sellar, postsellar), neurovascular protrusions, accessory septa, sex, and age.
resultsTwenty-seven studies involving 1263 observations were included. The pooled mean total sphenoid sinus volume was 9.30 cm
conclusionSphenoid sinus volume was significantly predicted by pneumatization type, neurovascular protrusions, septal complexity, sex, and age. These findings provide critical anatomical reference values to enhance surgical planning and reduce risk in skull base interventions.
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