Evidence map›Paper›PMID 42684208›Full record

ArticleJMIR AI2026

From Personalization to Therapeutic Continuity: Framework for Memory in AI-Powered Mental Health Systems.

Courtney Jewell, Kelsey McAlister, Tara Deliberto, Tanner Wallis, Grant Winns, Jennifer Huberty

Abstract read
In one paragraph

Article in JMIR AI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Courtney JewellFit Minded, Inc, 2901 E Greenway Rd PO Box 30271, Phoenix, AZ, 85046, United States, 1 (602) 935-6986.ORCID http://orcid.org/0009-0005-8359-299X
Kelsey McAlisterFit Minded, Inc, 2901 E Greenway Rd PO Box 30271, Phoenix, AZ, 85046, United States, 1 (602) 935-6986.ORCID http://orcid.org/0000-0003-1548-4936
Tara DelibertoYuna Health, San Francisco, CA, United States.ORCID http://orcid.org/0000-0003-1919-3538
Tanner WallisYuna Health, San Francisco, CA, United States.ORCID http://orcid.org/0009-0009-8737-7102
Grant WinnsYuna Health, San Francisco, CA, United States.ORCID http://orcid.org/0009-0002-9184-1499
Jennifer HubertyFit Minded, Inc, 2901 E Greenway Rd PO Box 30271, Phoenix, AZ, 85046, United States, 1 (602) 935-6986.ORCID http://orcid.org/0000-0002-0276-4640

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlabelled: AI-powered mental health tools are increasingly deployed to support users across multiple sessions, yet the field lacks a principled framework for how memory in these systems should be structured and applied. In most current implementations, memory functions primarily as a personalization mechanism, optimizing for conversational continuity and user engagement without distinguishing between types of information that have fundamentally different clinical relevance. We propose a framework organizing memory in AI-powered mental health systems into 4 functionally distinct types. Episodic memory captures discrete, time-bound experiences tied to specific events and context. Pattern memory, adapted from the concept of procedural memory in cognitive psychology, tracks recurring patterns in cognition, emotion, and behavior across sessions. Semantic memory captures stable, personally relevant background context about the user. State-responsive memory represents the user's current emotional and psychological condition in real time, taking priority over the other 3 types when acute distress or risk is signaled. Each type corresponds to a distinct therapeutically relevant function, and together they are designed to support the kind of cumulative, longitudinal understanding that effective mental health care requires. We term this framework "therapeutically informed memory," drawing on established memory systems research and applying it to the clinical requirements of AI-powered mental health support. The aim of this viewpoint paper is to give AI developers, clinicians, and mental health organizations a shared vocabulary and design framework for organizing memory around therapeutic function rather than personalization alone. This paper is intended primarily for AI product and engineering teams, clinical advisors to digital mental health companies, and researchers evaluating AI-powered mental health tools. We describe the design requirements and clinical rationale for each memory type, discuss how the types interact and how priority should be assigned across them, and use Yuna, an AI-powered digital mental health intervention developed with clinical input, as an illustrative example of how this framework can be applied in practice. We conclude with design implications for the field and identify open questions regarding memory quality metrics, outcome validation, and the ethical dimensions of persistent memory as priorities for future research.

Indexed as

AI safetyartificial intelligencecase formulationconversational agentsdigital mental health interventionlongitudinal carememorymental healthpersonalizationtherapeutic continuity

Identifiers

PMID42684208
PMCPMC13524310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.