Observational studyIndian journal of pharmacology2026
Evaluation of hydroxyurea effect in patients with sickle cell disease: A prospective observational study.
Observational study in Indian journal of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesSickle cell disease (SCD) is characterized by chronic hemolysis, inflammation, oxidative stress, and recurrent vaso-occlusive complications leading to significant morbidity. Hydroxyurea (HU), a widely used disease-modifying therapy, increases fetal hemoglobin (HbF) and reduces clinical complications. Emerging evidence suggests additional anti-inflammatory and antioxidant effects. The objectives of this study were to compare the inflammatory markers, oxidative stress markers, hematological parameters, and quality of life from baseline to 6 months after HU therapy among patients with SCD. MATERIALS AND
methodsIn this prospective observational study, 16 HU-naïve patients with SCD were evaluated at baseline and after 6 months of HU therapy. Investigations included inflammatory markers (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]), oxidative stress markers (malondialdehyde [MDA] and glutathione [GSH]), hematological parameters (HbF, sickle hemoglobin [HbS], leukocyte count, and neutrophil-to-lymphocyte ratio [NLR]), and quality of life assessed using the 36-Item Short Form Health Survey questionnaire.
resultsSignificant reductions in inflammatory markers were observed, with TNF-α decreasing from 5.82 ± 2.82 pg/mL to 4.64 ± 2.65 pg/mL (P = 0.006) and median IL-6 levels decreasing from 6.32 to 4.42 pg/mL (P = 0.001). Oxidative stress improved, with reduced MDA levels (P = 0.011) and increased GSH levels (P = 0.001). Hematological parameters showed significant improvement, including increased HbF and reductions in HbS, leukocyte count, and NLR (P < 0.001). HU therapy was well tolerated, with good compliance, improved quality of life, and a low incidence of complications.
conclusionHU may exert therapeutic benefit not only by increasing HbF but also through anti-inflammatory and antioxidant effects, leading to improved hematological stability and fewer complications in SCD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.