ReviewInvestigative and clinical urology2026
Engineered human adipose-derived stem cells delivering carboxylesterase and TRAIL for castration-resistant prostate cancer: Translational synthesis.
Review in Investigative and clinical urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Castration-resistant prostate cancer (CRPC) remains poorly controlled after sequential androgen receptor-targeted agents, taxanes, and radiopharmaceuticals. Tumor-tropic adipose-derived mesenchymal stem cells (ADSCs) offer a compelling platform for local delivery of gene-based therapeutics. This review synthesizes the mechanistic rationale, preclinical evidence, and translational strategy for hTERT-immortalized ADSCs engineered to express carboxylesterase (CE), secreted TRAIL (sTRAIL), or both, administered with irinotecan (CPT-11) in CRPC. We compared five studies from our group with independent work using mesenchymal stem cells, neural stem cells, and other carriers delivering CE- or TRAIL-based payloads, situating this platform within the broader field. Our studies used ubiquitin C promoter lentiviral vectors to express rabbit CE, rabbit CE2, human sTRAIL, or CE+sTRAIL. Efficacy was assessed mainly in subcutaneous PC3 xenografts and a PC3 tibial bone-metastasis model in male nude mice, using standardized migration, cytotoxicity, and apoptosis assays with
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