Evidence map›Paper›PMID 42683799›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2026

Characteristics and Mechanisms of Aperiodic Alternating Nystagmus.

Ji-Yun Park, Hyun Ah Kim, Jae-Hwan Choi, Eun Hye Oh, Chang-Hee Kim, Tae-Kyeong Lee, Seokho Choi, Seo Young Choi, Kwang-Dong Choi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ji-Yun ParkDepartment of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.ORCID https://orcid.org/0000-0002-7595-4517
Hyun Ah KimDepartment of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.ORCID https://orcid.org/0000-0002-2140-4763
Jae-Hwan ChoiDepartment of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.ORCID https://orcid.org/0000-0002-4120-9228
Eun Hye OhDepartment of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.ORCID https://orcid.org/0000-0001-7858-8930
Chang-Hee KimDepartment of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5667-861X
Tae-Kyeong LeeDepartment of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.ORCID https://orcid.org/0000-0001-6913-4689
Seokho ChoiDepartment of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Hospital, Busan, Korea.ORCID https://orcid.org/0009-0007-6375-2989
Seo Young ChoiDepartment of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Hospital, Busan, Korea.ORCID https://orcid.org/0000-0002-5320-7828
Kwang-Dong ChoiDepartment of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Hospital, Busan, Korea. kdchoi@pusan.ac.kr.ORCID https://orcid.org/0000-0002-9373-4710

Funding

National Research Foundation of Korea RS-2023-NR076583Ulsan University Hospital UUH-2024-10
6 · The paper itself

Abstract

background and purposeAperiodic alternating nystagmus (AAN) is defined as spontaneous alternating nystagmus in which the direction of nystagmus reverses repeatedly but the reversals do not occur at a consistent cycle interval and the cycle durations and/or peak slow-phase velocities are irregular. The etiologic distribution of vestibular disorders associated with AAN and the underlying mechanisms remain unclear. This study aimed to identify the clinical characteristics and potential underlying mechanisms of AAN.

methodsWe analyzed quantitative eye-movement recordings, audiovestibular test results, and neuroimaging results of 22 patients with AAN, and conducted a systematic review of reported cases of AAN in both peripheral and central vestibular disorders.

resultsThe systematic review identified an additional 29 patients with AAN. Peripheral vestibular causes accounted for 32 (62.7%) of all 51 patients, and comprised acute peripheral vestibulopathy (

conclusionsAAN can result from various peripheral and central vestibular disorders. Greater duration asymmetry, persistence of AAN, and accompanying ocular motor abnormalities can suggest a central origin, whereas reduced bithermal caloric responses may support a peripheral origin.

Indexed as

cerebellar vermispathologic nystagmusvestibular disordervestibulo-ocular reflex

Identifiers

PMID42683799
PMCPMC13553172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.