ArticleJournal of clinical neurology (Seoul, Korea)2026
SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health via Behavioral, Optimized, Organized Movement therapy (SUPERBRAIN-BOOM) in Mild Cognitive Impairment: Protocol for a Multicenter, Randomized Controlled Feasibility Trial.
Article in Journal of clinical neurology (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeThe SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention (SUPERBRAIN) showed that a multidomain lifestyle intervention targeting vascular risk, cognitive training, physical activity, nutrition, and motivation is feasible in older adults. However, its resource-intensive delivery limited scalability, and conventional aerobic exercise alone may not sufficiently support long-term adherence, cognitive-motor engagement, and cultural acceptability in older adults with mild cognitive impairment (MCI). To address these gaps, we developed the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health via Behavioral, Optimized, Organized Movement therapy (SUPERBRAIN-BOOM) in MCI, a mobile-based multidomain program integrating dance-based movement, nutrition education, and meditation.
methodsThis multicenter randomized feasibility trial will enroll 45 adults aged 50-85 years with MCI and at least one modifiable dementia risk factor. Participants will be randomized (1:1:1) to a tablet-based multidomain intervention, a smartphone-based multidomain intervention, or a control group receiving no intervention. The 12-week program consists of daily 30-minute home-based sessions (physical activity 20 minutes, nutrition education 5 minutes, meditation 5 minutes) delivered over four 3-week cycles, with assessments at weeks 3, 6, and 9 to adjust difficulty. The primary outcomes focus on feasibility (recruitment, retention, adherence ≥70%, and data completeness), and secondary outcomes include exploratory measures of cognition, physical function, vascular risk, nutrition, mood, quality of life, and motivation.
resultsRecruitment and data collection are ongoing.
conclusionsThis feasibility trial will inform the design of a future randomized trial evaluating a scalable, personalized mobile multidomain intervention for dementia prevention.
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