Evidence map›Paper›PMID 42683793›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2026

Deep Medullary Vein Disruption and Glymphatic Dysfunction Are Associated With Cognitive Impairment and Imaging Burden in Cerebral Small-Vessel Disease.

Junying Li, Weidong Wang, Jiaojiao Shi, Meiling Ding, Yiman Liu, Wenmin Zhang, Yuan Li, Xiang Chen, Jurong Ding, Xin Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junying Li *Department of Neurology, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0004-6169-9035
Weidong Wang *Department of Neurology, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0009-2042-5755
Jiaojiao ShiDepartment of Nutrition, General Hospital of Western Theater Command, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0009-2187-3306
Meiling DingSchool of Medicine, Sichuan University of Science and Engineering, Zigong, Sichuan, China.ORCID https://orcid.org/0009-0001-1074-9010
Yiman LiuSchool of Medicine, Sichuan University of Science and Engineering, Zigong, Sichuan, China.ORCID https://orcid.org/0009-0004-9270-8272
Wenmin ZhangDepartment of Neurology, Chengdu Seventh People's Hospital, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-6185-2421
Yuan LiDepartment of Neurology, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0003-7680-3416
Xiang ChenDepartment of Neurology, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0009-7938-8979
Jurong DingSchool of Medicine, Sichuan University of Science and Engineering, Zigong, Sichuan, China.ORCID https://orcid.org/0000-0001-6708-5131
Xin DingDepartment of Neurology, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, Sichuan, China. dingxin105@163.com.ORCID https://orcid.org/0000-0003-2417-3443

Funding

Health Commission of Chengdu Municipality 2022151Health Commission of Chengdu Municipality 2025452
6 · The paper itself

Abstract

background and purposeCerebral small-vessel disease (CSVD) is a major cause of cognitive impairment, but its underlying mechanisms remain incompletely understood. This study investigated the interrelationships among deep medullary vein (DMV) disruption, glymphatic dysfunction as assessed using the diffusion-tensor imaging analysis along the perivascular space (DTI-ALPS) index, CSVD imaging markers, and cognitive impairment.

methodsFifty CSVD patients were enrolled from Chengdu Second People's Hospital between January 2022 and December 2024, while 29 healthy controls (HCs) were recruited from the local community. DMV disruption was assessed using susceptibility-weighted imaging, while glymphatic function was evaluated using the DTI-ALPS index. Clinical characteristics, Mini-Mental State Examination (MMSE) scores, and CSVD imaging markers were collected, and regression and mediation analyses were performed.

resultsCompared with HCs, CSVD patients showed significantly lower DTI-ALPS indices, higher DMV scores, and worse cognition (all

conclusionsThis study found that DMV disruption and glymphatic dysfunction were associated with the CSVD imaging burden. Cognitive impairment was strongly associated with DMV disruption but weakly associated with glymphatic dysfunction. Combined assessments may provide complementary imaging markers for the CSVD severity and cognitive decline.

Indexed as

cerebral small vessel diseasescognitive dysfunctiondiffusion magnetic resonance imagingmagnetic resonance imagingperivascular spacessusceptibility-weighted

Identifiers

PMID42683793
PMCPMC13553180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.