ArticleFrontiers in pharmacology2026
Optimizing vancomycin therapy: the critical role of dosing frequency, AUC monitoring and gender: a retrospective cohort study.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Optimizing vancomycin therapy requires balancing efficacy and toxicity. Although therapeutic drug monitoring (TDM) guided by area-under-the-curve (AUC) measurements is now recommended, the effect of dosing frequency and patient-specific factors remain underexplored. This study examined the relationships of dosing frequency, pharmacokinetic/pharmacodynamic (PK/PD) parameters, clinical efficacy, and toxicities in patients receiving different vancomycin regimens. Methods: This retrospective cohort study analyzed 193 vancomycin dosing regimens in 148 adult patients who were treated at a tertiary teaching hospital in China between January 2013 and March 2021, 175 of which were guided by TDM. The full TDM-guided cohort (n = 175) was used for analysis of safety and PK; clinical efficacy was assessed in 59 culture-confirmed cases; and the association of PK/PD parameters with efficacy was examined in the 26 patients who received a 1 g q12 h regimen for staphylococcal infections. Results: In the subset of 26 patients with staphylococcal infections who received the 1 g q12 h regimen, clinical success was not significantly associated with C Conclusion: Among the 26 patients with staphylococcal infections receiving the 1 g q12 h regimen, traditional PK/PD targets (C
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