ArticleInternational journal of general medicine2026
Downregulation of miRNA-184 Promotes Nerve-Associated Angiogenesis via Vascular Endothelial Growth Factor A Following Ischemic Stroke.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The implication of several microRNAs in ischemic stroke and preclinical studies suggests that targeting these microRNAs could aid stroke recovery. MicroRNA-184 (miR-184) is downregulated in ischemic stroke in rats, and its downregulation contributes to corneal neovascularization. However, it is not clear whether miR-184 plays a part in angiogenesis following brain ischemia-reperfusion. We sought to determine if miR-184 participates in angiogenesis in response to ischemic stroke with the aim of identifying a targetable pathway to facilitate recovery after stroke. Patients and Methods: In this study, we investigated the effect of miR-184 on nerve-associated angiogenesis following brain ischemia-reperfusion by analyzing miR-184 expression levels in the peripheral blood of 10 healthy individuals and 15 individuals with ischemic stroke, a rat middle cerebral artery occlusion model, and human SH-SY5Y neuroblastoma cells co-cultured with human umbilical vein endothelial cells and subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) to model interactions between neurons and brain endothelial cells. We used luciferase reporter assays to evaluate downstream target expression and microscopy to observe nerve-associated angiogenesis. Results: We found that miR-184 expression was significantly downregulated in patients with ischemic stroke, rats subjected to middle cerebral artery occlusion, and human SH-SY5Y cells after OGD/R. Inhibition of miR-184 expression markedly promoted angiogenesis in vitro, as evidenced by increased numbers of vascular nodes, meshes and segments, and elevated vascular endothelial growth factor A expression. Luciferase reporter assays verified type 2 phosphatidic acid phosphatase B ( Conclusion: miR-184 is notably downregulated in brain tissue and cells in response to ischemia-reperfusion, thereby contributing to nerve-associated angiogenesis in vitro by enabling greater expression of
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