ArticleCancer diagnosis & prognosis
Prognostic Impact of Recurrence Location in Locally Recurrent Rectal Cancer: A Single-Center Retrospective Study.
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aim: Locally recurrent rectal cancer (LRRC) remains challenging, and optimal treatment strategies vary by recurrence location. We retrospectively evaluated treatment patterns and outcomes of LRRC without distant metastasis, focusing on the Memorial Sloan Kettering Cancer Center (MSKCC) pelvic compartment classification. Patients and Methods: We retrospectively analyzed 20 patients with LRRC without distant metastasis treated at our institution between 2005 and 2025. Recurrence sites were categorized as axial, anterior, posterior, or lateral according to the MSKCC classification. Treatment modalities, resection margin status, perioperative outcomes, and survival were analyzed. Results: The median interval from primary tumor resection to LRRC diagnosis was 30 months. Ten patients had axial recurrence, two anterior, two posterior, and six lateral recurrence. Seventeen patients underwent surgery (surgery alone, n=8; preoperative therapy plus surgery, n=9), while three patients received nonsurgical management; all nonsurgical cases were lateral recurrence. Median blood loss, operative time, and postoperative length of stay among surgical cases were 592 ml, 477 min, and 29 days, respectively. Major postoperative morbidity (Clavien-Dindo ≥IIIb) occurred in one axial patient (bladder injury). R1 and R2 resections were observed in four (23.6%) and one (5.9%) surgical cases, respectively. Posterior (2/2) and lateral (3/6) recurrences more frequently required preoperative therapy and showed a high rate of re-recurrence. When grouped as axial/anterior Conclusion: MSKCC-based location stratification may be clinically useful for LRRC treatment. Posterior and lateral recurrences were associated with poor outcomes even after surgery, suggesting the need for careful patient selection and consideration of alternative or intensified multimodal strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.