Evidence map›Paper›PMID 42683405›Full record

ArticleAnnals of gastroenterological surgery2026

CD86-Positive Mature Tertiary Lymphoid Structures Are Associated With CD8

Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki and 1 more

Abstract read
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In one paragraph

Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takaomi SekiDepartment of General Surgical Science Gunma University, Graduate School of Medicine Maebashi Gunma Japan.ORCID https://orcid.org/0000-0003-0915-6127
Kenichiro ArakiDepartment of General Surgical Science Gunma University, Graduate School of Medicine Maebashi Gunma Japan.ORCID https://orcid.org/0000-0002-5438-4551
Takehiko YokoboriDivision of Gene Therapy Science Gunma University, Initiative for Advanced Research (GIAR) Maebashi Gunma Japan.ORCID https://orcid.org/0000-0003-3284-4796
Hayato IkotaClinical Department of Pathology Gunma University Hospital Maebashi Gunma Japan.ORCID https://orcid.org/0009-0006-0289-314X
Norio KuboDepartment of General Surgical Science Gunma University, Graduate School of Medicine Maebashi Gunma Japan.ORCID https://orcid.org/0000-0003-2624-2529
Takamichi IgarashiDepartment of General Surgical Science Gunma University, Graduate School of Medicine Maebashi Gunma Japan.ORCID https://orcid.org/0000-0001-9077-2052
Mariko TsukagoshiDepartment of General Surgical Science Gunma University, Graduate School of Medicine Maebashi Gunma Japan.ORCID https://orcid.org/0000-0003-3748-9615
Norihiro IshiiDepartment of Surgery and Laparoscopic Surgery Gunma Prefecture Saiseikai Maebashi Hospital Maebashi Japan.ORCID https://orcid.org/0000-0001-6591-2439
Yasuo HosouchiDepartment of Surgery and Laparoscopic Surgery Gunma Prefecture Saiseikai Maebashi Hospital Maebashi Japan.
Hiroshi SaekiDepartment of General Surgical Science Gunma University, Graduate School of Medicine Maebashi Gunma Japan.
Ken ShirabeDepartment of General Surgical Science Gunma University, Graduate School of Medicine Maebashi Gunma Japan.ORCID https://orcid.org/0000-0002-7173-7945

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Although tertiary lymphoid structures (TLSs) contribute to antitumor immunity, the significance of CD86 expression within mature TLSs in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study evaluated CD86-positive mature TLSs as a marker of an immunologically active tumor microenvironment. Methods: We analyzed 128 treatment-naive patients with PDAC who underwent curative resection. TLSs were evaluated by hematoxylin and eosin staining and immunohistochemistry for CD4, CD8, CD20, CD21, CD23, and CD86. TLS maturation, CD86 expression, TLS density and diameter, intratumoral T-cell infiltration, and clinical outcomes were assessed. Multiplex immunofluorescence for CD8 and Granzyme B was performed in selected cases. Results: TLSs were identified in 124 patients. Among TLS-positive cases, 13, 21, and 90 were classified as immature, intermediate, and mature TLSs, respectively. Mature TLSs were associated with increased intratumoral CD8 Conclusion: CD86-positive mature TLSs may represent a pathological feature associated with an immunologically active tumor microenvironment in PDAC, as reflected by increased intratumoral CD8

Indexed as

antigen‐presenting B cellscluster of differentiation 86pancreatic ductal adenocarcinomaprognostic biomarkerstertiary lymphoid structures

Identifiers

PMID42683405
PMCPMC13532030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.