ArticleChemical science2026
Structure-guided engineering of an aptamer-PROTAC for targeted degradation of vaccinia-related kinase 1.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Vaccinia-related kinase 1 (VRK1) is an oncogenic serine/threonine kinase implicated in tumor progression, yet it remains an intractable target for catalytic degradation. Herein, we report the structure-guided design of a first aptamer-PROTAC chimera for potent and selective degradation of VRK1. Through structure-guided computational truncation and optimization of a parent DNA aptamer, we engineered a high-affinity variant (T4) with a 2.4-fold improved binding affinity (
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