ReviewIranian journal of basic medical sciences2026
Smart micro/nanoneedles for gene delivery.
Review in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene therapy, a transformative field in biomedicine, holds immense promise for treating a wide range of diseases. Smart micro/nanoneedles (MNs/NNs) emerged as non-viral carriers, offering safety and reduced immunogenicity, in addition to precise and controlled gene delivery, and represent promising platforms for gene delivery. They can also be tailored to respond to specific biological or environmental triggers, enabling precise targeting and localized delivery, ensuring that therapeutic genes reach their intended destination. Despite significant progress, challenges persist in scalable manufacturing, biocompatibility and safety, and genetic cargo stability. The incorporation of artificial intelligence (AI) into design and predictive modelling offers promising and cost-effective solutions to these limitations. This review provides a comprehensive analysis of MN/NN fabrication methodologies that enable structural and functional customization, while highlighting the interdisciplinary nature of MN/NN technologies and their transformative role in the future of gene therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.