ArticleIranian journal of basic medical sciences2026
Investigating the effects of taurine on Aβ-degradation proteins and neurogenesis-related genes in an LPS-induced neuroinflammatory SH-SY5Y cell model.
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Taurine, a brain-abundant sulfonic acid, shows potential neuroprotective effects and may counter neurodegenerative processes. This study investigated the effects of taurine on neuroinflammation, focusing on Aβ-degrading proteins and gene expression related to neurogenesis in an LPS-stimulated SH-SY5Y cell model. Materials and Methods: The effects of taurine (0.5 and 1 mg/ml) and LPS (0.5 and 10 μg/ml) on SH-SY5Y cell viability were assessed using the MTT assay. IL-1β and IL-6 expression was measured by real-time PCR, while matrix metalloproteinases (MMPs) and angiotensin-converting enzyme (ACE) levels were quantified via ELISA. Neurogenesis-related gene expression was evaluated using the Neurogenesis Plus RT² Profiler PCR array. Results: The MTT assay results demonstrated that taurine treatment at concentrations of 0.5 and 1 mg/ml significantly attenuated the cytotoxicity induced by LPS stimulation in SH-SY5Y cells. Also, treatment with taurine significantly reduced the expression levels of the inflammatory genes IL-1β and IL-6 in LPS-stimulated SH-SY5Y cells ( Conclusion: These results suggest that taurine may act as a potential neuroprotective agent by increasing the secretion of MMP-9 and ACE, regulating neurogenesis-related genes, and reducing LPS-induced neuroinflammation.
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