ArticleClinical, cosmetic and investigational dermatology2026
Squamous Cell Carcinoma Arising Within a Mycosis Fungoides Plaque: A Case Report.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Background: Squamous cell carcinoma (SCC) rarely develops within mycosis fungoides (MF) lesions. Recognizing a new epithelial malignancy within a longstanding MF plaque is important because clinical change may otherwise be attributed to lymphoma progression. Case Presentation: A 71-year-old man with a 30-year history of MF, no prior systemic therapy, psoralen plus ultraviolet A phototherapy, or topical chemotherapy, and limited prediagnostic narrowband ultraviolet B exposure developed a rapidly enlarging ulcerated mass within a lumbar MF plaque. Histopathology showed moderately differentiated keratinizing SCC adjacent to plaque-stage MF. Immunohistochemistry demonstrated a mixed CD4/CD8 lymphoid infiltrate; Ki-67 labeling was approximately 5% in the MF lymphoid compartment and 40-50% in SCC epithelial cells. Wide local excision with 1-cm margins, bilateral advancement flaps, and full-thickness skin grafting achieved clear margins. Results: Recovery was uncomplicated, and no clinical recurrence was detected at 6 months. The surrounding MF plaques appeared less erythematous and infiltrated, although the significance of this observation is uncertain. Conclusion: A rapidly growing, ulcerated, or otherwise changing lesion within longstanding MF warrants prompt biopsy to exclude a second cutaneous malignancy. Compartment-specific interpretation of immunohistochemical findings is essential, and surgical excision can be feasible in MF-affected skin.
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