Evidence map›Paper›PMID 42683256›Full record

ArticleAnnals of gastroenterological surgery2026

Mac-2 Binding Protein Glycosylation Isomer (M2BPGi)-Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma.

Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi

Abstract read
In one paragraph

Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kojiro ShirabeDepartment of Surgery and Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Junya MitaDepartment of Surgery and Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Shinji ItohDepartment of Surgery and Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.ORCID https://orcid.org/0000-0003-0382-2520
Takeo ToshimaDepartment of Surgery and Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.ORCID https://orcid.org/0000-0003-4019-8288
Yoshiyuki KitamuraDepartment of Clinical Radiology, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Norifumi IsedaDepartment of Surgery and Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.ORCID https://orcid.org/0000-0001-8589-0038
Takuro IsodaDepartment of Clinical Radiology, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Kousei IshigamiDepartment of Clinical Radiology, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Tomoharu YoshizumiDepartment of Surgery and Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.ORCID https://orcid.org/0000-0002-4497-1816

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To evaluate the prognostic significance of preoperative Mac-2 binding protein glycosylation isomer (M2BPGi) and determine whether tumor metabolic activity provides additional risk stratification after hepatic resection for hepatocellular carcinoma (HCC). Methods: We retrospectively analyzed 291 patients with HCC who underwent hepatic resection at a single Japanese institution between 2015 and 2023 and had available preoperative M2BPGi and 18F-fluorodeoxyglucose positron emission tomography/computed tomography data. Associations with clinicopathological features, recurrence-free survival (RFS), and overall survival (OS) were evaluated. Results: High M2BPGi was associated with impaired liver function and F3-F4 fibrosis but not with tumor-related features or tumor metabolic activity. In contrast, high tumor metabolic activity was associated with higher des- Conclusions: Preoperative M2BPGi identifies fibrosis-related risk after HCC resection, whereas tumor metabolic activity further distinguishes patients with particularly poor outcomes.

Indexed as

hepatic fibrosishepatic resectionhepatocellular carcinomaMac‐2 binding protein glycosylation isomertumor metabolism

Identifiers

PMID42683256
PMCPMC13531093

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.