Evidence map›Paper›PMID 42683190›Full record

ArticleBrain communications2026

Elevated intron retention implicates neuroinflammation in brains of individuals with alcohol use disorder.

Rudong Li, Jill L Reiter, Season K Wyatt-Johnson, Chuanpeng Dong, Caine S Smith, Nick Green, Hongyu Gao, Sheketha R Hauser, Manav Kapoor, Julia Stevens and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rudong LiCenter for Computational Biology and Bioinformatics (CCBB), Indiana University (IU) School of Medicine, Indianapolis, IN 46202, USA.ORCID https://orcid.org/0000-0002-2389-1737
Jill L ReiterCenter for Computational Biology and Bioinformatics (CCBB), Indiana University (IU) School of Medicine, Indianapolis, IN 46202, USA.
Season K Wyatt-JohnsonDepartment of Microbiology and Immunology, IU School of Medicine, Indianapolis, IN 46202, USA.
Chuanpeng DongCenter for Computational Biology and Bioinformatics (CCBB), Indiana University (IU) School of Medicine, Indianapolis, IN 46202, USA.
Caine S SmithNew South Wales (NSW) Brain Tissue Research Centre, University of Sydney, Sydney, NSW 2006, Australia.
Nick GreenCenter for Computational Biology and Bioinformatics (CCBB), Indiana University (IU) School of Medicine, Indianapolis, IN 46202, USA.
Hongyu GaoCenter for Computational Biology and Bioinformatics (CCBB), Indiana University (IU) School of Medicine, Indianapolis, IN 46202, USA.
Sheketha R HauserStark Neurosciences Research Institute, IU School of Medicine, Indianapolis, IN 46202, USA.
Manav KapoorRonald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Julia StevensNew South Wales (NSW) Brain Tissue Research Centre, University of Sydney, Sydney, NSW 2006, Australia.
R Dayne MayfieldWaggoner Center for Alcohol and Addiction Research (WCAAR), University of Texas at Austin, Austin, TX 78712, USA.
Alison GoateRonald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Yue WangDepartment of Medical and Molecular Genetics (MMGE), IU School of Medicine, Indianapolis, IN 46202, USA.
Howard J EdenbergDepartment of Medical and Molecular Genetics (MMGE), IU School of Medicine, Indianapolis, IN 46202, USA.
Richard L BellDepartment of Psychiatry, IU School of Medicine, Indianapolis, IN 46202, USA.
Greg Trevor SutherlandNew South Wales (NSW) Brain Tissue Research Centre, University of Sydney, Sydney, NSW 2006, Australia.
Randy BrutkiewiczDepartment of Microbiology and Immunology, IU School of Medicine, Indianapolis, IN 46202, USA.ORCID https://orcid.org/0000-0002-7396-480X
Yunlong LiuCenter for Computational Biology and Bioinformatics (CCBB), Indiana University (IU) School of Medicine, Indianapolis, IN 46202, USA.ORCID https://orcid.org/0000-0002-2699-626X

Funding

Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
NIAAA NIH HHS R28 AA012725
6 · The paper itself

Abstract

Intron retention, a form of alternative RNA splicing, can occur as part of normal gene regulation or result from disruption of the splicing machinery. Retained introns can potentially form double-stranded RNA, activating innate immune sensors and inflammation. This mechanism has been implicated in cancer but has not been studied in neuropsychiatric diseases like alcohol use disorder. We systematically analysed transcriptome-wide intron retention events in

Indexed as

alcohol-preferring P ratsalcohol use disorderdouble-stranded RNAintron retentionneuroinflammation

Identifiers

PMID42683190
PMCPMC13532580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.