Evidence map›Paper›PMID 42683181›Full record

ReviewRSC advances2026

Injectable hydrogels for bone regeneration: from materials design to clinical translation.

Xinyue Zhang, Zheng Zhuang, Bo Liu, Mengjia Wu, Chenfei Lu, Zhan Zhang, Zilu Zhang, Xueyan Zhang, Yanguo Wang, Hao Hu

Abstract readReview
In one paragraph

Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinyue ZhangCollege of Materials Science and Engineering, Qingdao University Qingdao 266071 China.
Zheng ZhuangCollege of Materials Science and Engineering, Qingdao University Qingdao 266071 China.
Bo LiuDepartment of Orthopedics, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University Qingdao 266035 China.
Mengjia WuCollege of Materials Science and Engineering, Qingdao University Qingdao 266071 China.
Chenfei LuCollege of Materials Science and Engineering, Ocean University of China Qingdao 266100 China huhao@ouc.edu.cn.
Zhan ZhangCollege of Materials Science and Engineering, Qingdao University Qingdao 266071 China.
Zilu ZhangCollege of Materials Science and Engineering, Qingdao University Qingdao 266071 China.
Xueyan ZhangMarine Biomedical Research Institute of Qingdao Qingdao 266100 China.
Yanguo WangDepartment of Orthopedics, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University Qingdao 266035 China.
Hao HuCollege of Materials Science and Engineering, Qingdao University Qingdao 266071 China.ORCID https://orcid.org/0000-0003-4796-9882

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical repair of bone defects has long faced challenges including the limited availability of autografts, immunological rejection of allografts, and mechanical mismatch of traditional implants. Injectable hydrogels have emerged as highly promising strategies in bone tissue engineering due to their unique advantages: minimally invasive implantation, the ability to conform to irregular defect cavities, excellent biocompatibility, and high functional tunability. This review systematically outlines recent advances in injectable hydrogels for bone regeneration. It comprehensively outlines material classifications and fundamental properties. Specifically, it analyzes key design strategies, including enhancing mechanical support through cross-linking optimization and the incorporation of reinforcing phases, reconstructing the regenerative microenvironment

Identifiers

PMID42683181
PMCPMC13530895

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.