Evidence map›Paper›PMID 42683146›Full record

ArticleJournal of human immunity2026

Prevalence of neutralizing autoantibodies against type I interferon in dengue patients.

Mengtian Yang, Yixin Liao, Xiaorong Yang, Jiaqi Fan, Min Liao, Yongchang Wu, Huiqin Yang, Jian Wang, Wei Zhang, Feng Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengtian Yang *Institute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0004-4873-8714
Yixin Liao *Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0001-1436-787X
Xiaorong YangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0006-6134-5987
Jiaqi FanInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-7269-9090
Min LiaoInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0001-5855-6509
Yongchang WuInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0005-2448-6548
Huiqin YangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-3858-6142
Jian WangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0005-3098-9352
Wei ZhangDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-9262-849X
Feng LiInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-3169-6349
Haisheng YuInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-1757-1411
Yun LingDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4289-3594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of neutralizing autoantibodies (NAbs) against type I IFN (IFN-I) has been associated with severe complications arising from various viral infections. However, the prevalence of IFN-I NAbs in dengue virus (DENV) infection remains unclear. Here, we enrolled 216 hospitalized dengue patients in 2024, including 7 individuals with dengue shock syndrome (DSS) and 42 individuals with dengue hemorrhagic fever (DHF). Utilizing a sensitive luciferase reporter assay, IFN-I NAbs were detected in 7 patients (14.3% of DSS/DHF cases), and their neutralizing ability was further validated in DENV-infected cells. Notably, all NAb-positive patients exhibited plasma leakage tendency and cardiac injury and were significantly older than the overall cohort (75.34 vs. 50.75, P

Identifiers

PMID42683146
PMCPMC13532549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.