ArticleJournal of blood medicine2026
Longstanding Microcytosis with a Thalassaemia-Like Phenotype and Inconclusive Molecular Testing: A Case Report.
Article in Journal of blood medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Persistent microcytosis in adults with normal or only mildly reduced haemoglobin usually prompts investigation for iron deficiency or thalassaemia trait. In some patients, however, the cause remains uncertain despite haemoglobin fractionation and targeted molecular testing. Case Presentation: An asymptomatic adult male had longstanding microcytosis, with haemoglobin of 13.6 g/dL, a red blood cell count of 5.67 × 10 Interpretation: The longstanding microcytosis, relatively preserved red blood cell count, normal HbA Conclusion: This case highlights the difficulty of interpreting a stable microcytic phenotype when molecular testing does not establish a causative abnormality. Molecular findings should be considered alongside the longitudinal haematological pattern and interpreted within the analytical scope of the methods used. Iron treatment should be reserved for patients in whom iron deficiency has been demonstrated by appropriate testing.
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