Evidence map›Paper›PMID 42683128›Full record

Article... International Conference on Learning Representations2026

Bi-Lipschitz Autoencoder With Injectivity Guarantee.

Qipeng Zhan, Zhuoping Zhou, Zexuan Wang, Qi Long, Li Shen

Abstract read
In one paragraph

Article in ... International Conference on Learning Representations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qipeng ZhanUniversity of Pennsylvania.
Zhuoping ZhouUniversity of Pennsylvania.
Zexuan WangUniversity of Pennsylvania.
Qi LongUniversity of Pennsylvania.
Li ShenUniversity of Pennsylvania.

Funding

Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2022 to 2025
$6.7M
Robust and Interpretable Multi-modal AI/ML for Precision MedicineR01EB037101 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Tianlong Chen · 2025 to 2026
$1.4M
NIA NIH HHS U01 AG066833NIA NIH HHS U01 AG068057NIBIB NIH HHS R01 EB037101
6 · The paper itself

Abstract

Autoencoders are widely used for dimensionality reduction, based on the assumption that high-dimensional data lies on low-dimensional manifolds. Regularized autoencoders aim to preserve manifold geometry during dimensionality reduction, but existing approaches often suffer from non-injective mappings and overly rigid constraints that limit their effectiveness and robustness. In this work, we identify encoder non-injectivity as a core bottleneck that leads to poor convergence and distorted latent representations. To ensure robustness across data distributions, we formalize the concept of admissible regularization and provide sufficient conditions for its satisfaction. In this work, we propose the Bi-Lipschitz Autoencoder (BLAE), which introduces two key innovations: (1) an injective regularization scheme based on a separation criterion to eliminate pathological local minima, and (2) a bi-Lipschitz relaxation that preserves geometry and exhibits robustness to data distribution drift. Empirical results on diverse datasets show that BLAE consistently outperforms existing methods in preserving manifold structure while remaining resilient to sampling sparsity and distribution shifts. Code is available at https://github.com/qipengz/BLAE.

Identifiers

PMID42683128
PMCPMC13532366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.