Evidence map›Paper›PMID 42683103›Full record

ArticleInternational journal of reproductive biomedicine2026

Evaluation of intralipid effect on pregnancy outcomes in women with recurrent implantation failure: A retrospective cohort study.

Atoosa Karimi, Aniseh Dadgar, Haniyeh Saffari, Nazanin Vahedi, Sasan Saket, Soheila Arefi

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Article in International journal of reproductive biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Atoosa KarimiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Aniseh DadgarDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Haniyeh SaffariReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Nazanin VahediReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Sasan SaketDepartment of Pediatric Neurology, School of Medicine, Mofid Children's Hospital, Iranian Child Neurology Center of Excellence (ICNCE), Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soheila ArefiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recurrent implantation failure remains a challenge in assisted reproduction. Intralipid has been proposed as an immunomodulatory intervention to improve outcomes, although evidence remains inconsistent. Objective: This study aimed to evaluate the effect of intralipid on pregnancy outcomes in women with a history of at least 2 failed embryo transfer cycles. Materials and Methods: In this retrospective cohort study, data of 270 women with Results: Biochemical pregnancy rate was significantly higher in the intralipid group compared with controls (51.5% vs. 37.7%, p = 0.022). Clinical pregnancy (43.2% vs. 36.2%), ongoing pregnancy (28.8% vs. 18.8%), and live birth (25.8% vs. 17.4%) also favored the intralipid group, although these differences did not reach statistical significance (p Conclusion: Intralipid may improve biochemical pregnancy rates and shows a non-significant positive trend in other pregnancy outcomes in recurrent implantation failure cases, warranting confirmation in larger randomized controlled trials.

Indexed as

Embryo implantation failureFat emulsionsFertilization in vitroImmunomodulation.IntravenousPregnancy outcome

Identifiers

PMID42683103
PMCPMC13530875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.